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Tytuł pozycji:

Pharmacokinetics of ceftriaxone in freshwater crocodiles (Crocodylus siamensis) after intramuscular administration at two dosages.

Tytuł :
Pharmacokinetics of ceftriaxone in freshwater crocodiles (Crocodylus siamensis) after intramuscular administration at two dosages.
Autorzy :
Poapolathep S; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Giorgi M; Department of Veterinary Sciences, University of Pisa, San Piero a Grado, Italy.
Chaiyabutr N; Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Klangkaew N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Phaochoosak N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Wongwaipairote T; Wongweerakij Crocodile Farm, Bo Phloi, Kanjanaburi, Thailand.
Poapolathep A; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
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Źródło :
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2020 Mar; Vol. 43 (2), pp. 141-146. Date of Electronic Publication: 2019 Jul 29.
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
Język :
English
Imprint Name(s) :
Original Publication: Oxford, Blackwell Scientific Publications.
MeSH Terms :
Alligators and Crocodiles/*blood
Anti-Bacterial Agents/*pharmacokinetics
Ceftriaxone/*pharmacokinetics
Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/blood ; Area Under Curve ; Ceftriaxone/administration & dosage ; Ceftriaxone/blood ; Dose-Response Relationship, Drug ; Half-Life ; Hemangioma
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Grant Information :
: RSA6180033 Thailand Research Fund
Contributed Indexing :
Keywords: LC-MS/MS; ceftriaxone; freshwater crocodiles; pharmacokinetics
Substance Nomenclature :
0 (Anti-Bacterial Agents)
75J73V1629 (Ceftriaxone)
Entry Date(s) :
Date Created: 20190730 Date Completed: 20201209 Latest Revision: 20201214
Update Code :
20211106
DOI :
10.1111/jvp.12801
PMID :
31353505
Czasopismo naukowe
One of the major obstacles to the successful treatment of infectious disease in freshwater crocodile species is incorrect dosing of antibiotics. There are few reports on pharmacokinetics and dosage regimens of antimicrobial drugs in crocodiles. The purpose of the present study was to clarify the pharmacokinetic characteristics of ceftriaxone (CEF) in Siamese freshwater crocodiles (Crocodylus siamensis). Freshwater crocodiles, Crocodylus siamensis, in breeding farms were treated with a single intramuscular administration of CEF at two dosages, 12.5 and 25 mg/kg body weight (b.w.). Blood samples were collected at preassigned times up to 168 hr. The plasma concentrations of CEF were measured by a validated method through liquid chromatography tandem-mass spectrometry. CEF plasma concentrations were quantified up to 72 and 96 hr after low- and high-dose administration, respectively. The C max values of CEF were 24.61 ± 5.15 µg/ml and 26.39 ± 2.81 µg/ml at dosages of 12.5 and 25 mg/kg b.w., respectively. The AUC last values increased in a dose-dependent fashion. The half-life values were not statistically different between the groups (around 20 hr). The average binding percentage of CEF to plasma protein was 53.78 ± 2.11%. Based on the pharmacokinetic data, susceptibility break-point and the surrogate PK-PD index (T > MIC, 0.2 μg/ml), i.m. administration of CEF at a dose of 12.5 mg/kg b.w. might be appropriate for initiating treatment of susceptible bacterial infections in freshwater crocodiles.
(© 2019 John Wiley & Sons Ltd.)

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