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Tytuł:
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Spectral Computed Tomographic Parameters Predict the Therapeutic Efficacy and Overall Survival of the Angiogenesis Inhibitor AL3818 in Hepatic Lesions: Preliminary Animal Study.
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Autorzy:
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Zhou Y; From the Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan.
Gong Y; Department of Radiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.
Wang M; From the Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan.
Xu H; Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University.
Hou P; From the Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan.
Dong J; From the Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan.
Wang F; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Gao JB; From the Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan.
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Źródło:
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Journal of computer assisted tomography [J Comput Assist Tomogr] 2019 Sep/Oct; Vol. 43 (5), pp. 721-728.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2000->: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, Raven Press.
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MeSH Terms:
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Tomography, X-Ray Computed*
Angiogenesis Inhibitors/*pharmacology
Indoles/*pharmacology
Liver Neoplasms/*diagnostic imaging
Liver Neoplasms/*drug therapy
Quinolines/*pharmacology
Animals ; Contrast Media ; Disease Models, Animal ; Iohexol/analogs & derivatives ; Predictive Value of Tests ; Prognosis ; Rabbits ; Radiographic Image Interpretation, Computer-Assisted
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Substance Nomenclature:
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0 (Angiogenesis Inhibitors)
0 (Contrast Media)
0 (Indoles)
0 (Quinolines)
0 (anlotinib)
4419T9MX03 (Iohexol)
712BAC33MZ (iopromide)
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Entry Date(s):
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Date Created: 20190730 Date Completed: 20191021 Latest Revision: 20200108
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Update Code:
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20240105
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DOI:
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10.1097/RCT.0000000000000898
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PMID:
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31356519
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Objective: This study aimed to investigate the predictive and prognostic values of repeated spectral computed tomographic (CT) parameter changes for the prediction of treatment responses to the angiogenesis inhibitor AL3818 in hepatic tumors.
Methods: A total of 30 rabbits with VX2 hepatic tumors that underwent spectral contrast-enhanced abdominal CT before and during treatment were included in the study. The percent change (Δ, %) of the normalized iodine concentration (nIC) during the arterial phase (AP) and venous phase (VP) was used to predict the tumor response and to calculate the overall survival (OS). The threshold of the nIC for tumor response prediction and prognostic significance was determined by a receiver operating characteristic curve and Kaplan-Meier analysis.
Results: After treatment, there were 43% (13/30) responders and 57% (17/30) nonresponders. When ΔnICAP ≥ -13.10% was used as the threshold, the sensitivity and specificity for the prediction of tumor response were 82.41% and 92.31%, respectively. ΔnICVP resulted in 88.20% sensitivity and 76.92% specificity for cutoff values ≥10.78%. Kaplan-Meier analyses showed that high ΔnICAP and ΔnICVP were associated with improved OS.
Conclusions: The current study shows the capability of the changes (Δ) in repeated spectral CT parameters to predict the tumor response during antiangiogenesis therapy in small hepatic tumors. ΔnICAP and ΔnICVP were predictors for treatment response and were associated with OS.
