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Tytuł pozycji:

[Young male patient with unusual space-occupying lesion of the lower eyelid].

Tytuł:
[Young male patient with unusual space-occupying lesion of the lower eyelid].
Autorzy:
Rokohl AC; Zentrum für Augenheilkunde, Universität zu Köln, Medizinische Fakultät und Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland. .
Löser H; Institut für Pathologie, Medizinische Fakultät und Uniklinik Köln, Universität zu Köln, Köln, Deutschland.
Mor JM; Zentrum für Augenheilkunde, Universität zu Köln, Medizinische Fakultät und Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.
Loreck N; Zentrum für Augenheilkunde, Universität zu Köln, Medizinische Fakultät und Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.
Koch KR; Zentrum für Augenheilkunde, Universität zu Köln, Medizinische Fakultät und Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.
Heindl LM; Zentrum für Augenheilkunde, Universität zu Köln, Medizinische Fakultät und Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.; Centrum für Integrierte Onkologie (CIO) Aachen - Köln - Bonn - Düsseldorf, Köln, Deutschland.
Transliterated Title:
Junger Patient mit ungewöhnlicher Raumforderung am Unterlid.
Źródło:
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft [Ophthalmologe] 2020 Jan; Vol. 117 (1), pp. 73-77.
Typ publikacji:
Case Reports; Journal Article
Język:
German
Imprint Name(s):
Original Publication: Berlin ; New York : Springer-Verlag, c1992-
MeSH Terms:
Carcinoma, Basal Cell*
Eyelid Neoplasms*
Hair Diseases*
Molluscum Contagiosum*
Skin Neoplasms*
Adult ; Humans ; Male
References:
Ophthalmologe. 2017 Mar;114(3):224-236. (PMID: 27752782)
Travel Med Infect Dis. 2013 Nov-Dec;11(6):435-7. (PMID: 24201041)
Z Kinderchir. 1987 Aug;42(4):250-1. (PMID: 3673286)
Int J Radiat Oncol Biol Phys. 1990 Aug;19(2):235-42. (PMID: 2394605)
J Dtsch Dermatol Ges. 2019 Jan;17(1):94-103. (PMID: 30592557)
Ophthalmologe. 2001 Jun;98(6):555-9. (PMID: 11450480)
Klin Monbl Augenheilkd. 2017 Oct 09;:null. (PMID: 28992656)
Ophthalmologe. 2016 Dec;113(12):1095-1108. (PMID: 27878368)
Arch Dermatol. 2000 Mar;136(3):370-2. (PMID: 10724199)
Ophthalmologe. 2019 Mar;116(3):273-277. (PMID: 29777299)
JAMA Ophthalmol. 2013 Oct;131(10):1364-6. (PMID: 23907144)
J Dtsch Dermatol Ges. 2013 Jun;11 Suppl 3:10-5, 11-6. (PMID: 23734889)
J Skin Cancer. 2017;2017:2692604. (PMID: 29464122)
Klin Monbl Augenheilkd. 2018 Dec;235(12):1415-1428. (PMID: 30469156)
Ophthalmologe. 2016 Apr;113(4):309-13. (PMID: 26487192)
Ophthalmology. 2009 Apr;116(4):802-6. (PMID: 19232734)
Onco Targets Ther. 2017 May 08;10:2483-2489. (PMID: 28507440)
Clin Dermatol. 2017 Nov - Dec;35(6):517-529. (PMID: 29191344)
Entry Date(s):
Date Created: 20190731 Date Completed: 20200123 Latest Revision: 20200123
Update Code:
20240105
DOI:
10.1007/s00347-019-00948-y
PMID:
31359135
Czasopismo naukowe
Background: A space-occupying lesion of the eyelid in young adults is often a sign of an inflammation, a trauma or a benign neoplasm. The aim of this case report is to demonstrate a rare basal cell carcinoma, which presumably already arose in adolescence without further high-risk factors.
Methods: A 28-year-old male patient presented for a second opinion on a painless swelling of the right lower eyelid. According to the patient's history the swelling had been present since the age of 16 years and originally resembled a molluscum contagiosum. An ophthalmologist in private practice made the diagnosis of a suspected trichoepithelioma. The extended patient history revealed a blood coagulation disorder. The clinical ophthalmological examination revealed a nodular space-occupying lesion with a border wall and telangiectasia. The further ophthalmological examination was bilaterally inconspicuous. Due to the suspicion of a malignant process, an operation was promptly carried out using local anesthesia with complete tumor excision and pedicled flap plasty as well as a histopathological investigation to confirm the diagnosis.
Results: The histopathological investigation revealed underlying infiltrates of a basaloid tumor with bale-shaped trabecular growth, sometimes with peripheral palisading of the cells. The cells were predominantly monomorphic with isolated pleomorphic nuclei and sometimes enclosed mitoses. Immunohistochemically the cells were strongly positive for BerEP4 and negative for epithelial membrane antigen (EMA). The diagnosis of a nodular basal cell carcinoma of the right lower eyelid was made. All incision margins were free of tumor cells (R0 resection). In the dermatological screening no further manifestations were detected.
Conclusion: Despite the occurrence of a space-occupying lesion of the eyelid in a young adult patient and also with no further risk factors, in addition to an inflammatory event and a benign tumor, a malignant disease, such as a basal cell carcinoma should also be taken into consideration. A tissue biopsy or complete excision with subsequent histological examination including an immunohistochemical analysis are essential for differentiation from other tumor entities.

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