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Tytuł:
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Spray dried curcumin loaded nanoparticles for antimicrobial photodynamic therapy.
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Autorzy:
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Preis E; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany. Electronic address: .
Baghdan E; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany. Electronic address: .
Agel MR; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany. Electronic address: .
Anders T; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany. Electronic address: .
Pourasghar M; Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Campus C4 1, 66123 Saarbrücken, Germany. Electronic address: .
Schneider M; Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Campus C4 1, 66123 Saarbrücken, Germany. Electronic address: .
Bakowsky U; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany. Electronic address: .
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Źródło:
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2019 Sep; Vol. 142, pp. 531-539. Date of Electronic Publication: 2019 Jul 27.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier Science
Original Publication: Stuttgart : Wissenschaftliche Verlagsgesellschaft, c1991-
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MeSH Terms:
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Anti-Bacterial Agents/*chemistry
Curcumin/*chemistry
Nanoparticles/*chemistry
Administration, Inhalation ; Anti-Bacterial Agents/pharmacology ; Chemistry, Pharmaceutical/methods ; Drug Compounding/methods ; Drug Delivery Systems/methods ; Dry Powder Inhalers/methods ; Escherichia coli/drug effects ; Excipients/chemistry ; Mannitol/chemistry ; Particle Size ; Photochemotherapy/methods ; Powders/chemistry ; Staphylococcus saprophyticus/drug effects
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Contributed Indexing:
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Keywords: Antimicrobial; Curcumin; Nanoparticles; Photodynamic therapy; Pulmonary drug delivery; Spray drying
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
0 (Excipients)
0 (Powders)
3OWL53L36A (Mannitol)
IT942ZTH98 (Curcumin)
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Entry Date(s):
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Date Created: 20190731 Date Completed: 20191125 Latest Revision: 20191125
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Update Code:
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20240105
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DOI:
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10.1016/j.ejpb.2019.07.023
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PMID:
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31362056
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Antimicrobial resistance is one of the most serious problems that researchers of multiple disciplines are working on. The number of new antibiotics and their targeted structures have continuously decreased emphasizing the demand of alternative therapy for bacterial infections. Photodynamic therapy is such a promising strategy that has been proven to be effective against a wide range of bacterial strains. In this study, an inhalable nanoformulation for photodynamic therapy against respiratory infections was developed in the form of nano-in-microparticles consisting of curcumin nanoparticles embedded in a mannitol matrix. The produced nano-in-microparticles exhibited suitable aerodynamic properties with a mass median aerodynamic diameter of 2.88 ± 0.13 µm and a high fine particle fraction of 60.99 ± 9.50%. They could be readily redispersed in an aqueous medium producing the original nanoparticles without any substantial changes in their properties. This was confirmed using dynamic light scattering and electron microscopy. Furthermore, the redispersed nanoparticles showed an efficient antibacterial photoactivity causing 99.99992% (6.1log 10 ) and 97.75% (1.6log 10 ) reduction in the viability of Staphylococcus saprophyticus subsp. bovis and Escherichia coli DH5 alpha respectively. Based on these findings, it can be concluded that nano-in-microparticles represent promising drug delivery systems for antimicrobial photodynamic therapy.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
