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Tytuł:
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Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation.
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Autorzy:
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Qazi R; School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.; Department of Electrical, Computer, and Energy Engineering, University of Colorado, Boulder, CO, USA.
Gomez AM; Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO, USA.
Castro DC; Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Zou Z; Department of Mechanical Engineering, University of Colorado, Boulder, CO, USA.
Sim JY; Welfare & Medical ICT Research Department, Electronics and Telecommunications Research Institute, Daejeon, Republic of Korea.
Xiong Y; Department of Electrical, Computer, and Energy Engineering, University of Colorado, Boulder, CO, USA.
Abdo J; Department of Electrical, Computer, and Energy Engineering, University of Colorado, Boulder, CO, USA.
Kim CY; School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Anderson A; Department of Electrical, Computer, and Energy Engineering, University of Colorado, Boulder, CO, USA.
Lohner F; Department of Electrical, Computer, and Energy Engineering, University of Colorado, Boulder, CO, USA.
Byun SH; School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Chul Lee B; Center for BioMicrosystems, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Jang KI; Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
Xiao J; Department of Mechanical Engineering, University of Colorado, Boulder, CO, USA.
Bruchas MR; Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO, USA. .; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA. .; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA. .; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA. .; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA. .; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA. .; Department of Pharmacology, University of Washington, Seattle, WA, USA. .; Department of Bioengineering, University of Washington, Seattle, WA, USA. .
Jeong JW; School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. .; Department of Electrical, Computer, and Energy Engineering, University of Colorado, Boulder, CO, USA. .
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Źródło:
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Nature biomedical engineering [Nat Biomed Eng] 2019 Aug; Vol. 3 (8), pp. 655-669. Date of Electronic Publication: 2019 Aug 05.
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Typ publikacji:
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Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: London : Springer Nature
Original Publication: [London] : Macmillan Publishers Limited, [2016]-
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MeSH Terms:
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Neuropharmacology/*methods
Optogenetics/*instrumentation
Wireless Technology/*instrumentation
Animals ; Brain/physiology ; Brain Diseases ; Deep Brain Stimulation/methods ; Drug Delivery Systems/instrumentation ; Drug Delivery Systems/methods ; Implants, Experimental ; Lab-On-A-Chip Devices ; Locomotion ; Male ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Neuropharmacology/instrumentation ; Optogenetics/methods
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Grant Information:
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F32 DA043999 United States DA NIDA NIH HHS
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Entry Date(s):
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Date Created: 20190807 Date Completed: 20200305 Latest Revision: 20210619
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Update Code:
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20240105
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DOI:
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10.1038/s41551-019-0432-1
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PMID:
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31384010
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Both in vivo neuropharmacology and optogenetic stimulation can be used to decode neural circuitry, and can provide therapeutic strategies for brain disorders. However, current neuronal interfaces hinder long-term studies in awake and freely behaving animals, as they are limited in their ability to provide simultaneous and prolonged delivery of multiple drugs, are often bulky and lack multifunctionality, and employ custom control systems with insufficiently versatile selectivity for output mode, animal selection and target brain circuits. Here, we describe smartphone-controlled, minimally invasive, soft optofluidic probes with replaceable plug-like drug cartridges for chronic in vivo pharmacology and optogenetics with selective manipulation of brain circuits. We demonstrate the use of the probes for the control of the locomotor activity of mice for over four weeks via programmable wireless drug delivery and photostimulation. Owing to their ability to deliver both drugs and photopharmacology into the brain repeatedly over long time periods, the probes may contribute to uncovering the basis of neuropsychiatric diseases.
