Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey.

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Tytuł:: Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey.
Autorzy:: Flamand C; Epidemiology Unit, Cayenne, French Guiana.
Bailly S; Epidemiology Unit, Cayenne, French Guiana.
Fritzell C; Epidemiology Unit, Cayenne, French Guiana.
Berthelot L; Arbovirus National Reference Center, Institut Pasteur, Cayenne, French Guiana.
Vanhomwegen J; Environment and Infectious Risks Unit, Unité Mixte de Recherche 2000, Centre National de la Recherche Scientifique, Paris, France.
Salje H; Mathematical Modelling of Infectious Diseases Unit, Unité Mixte de Recherche 2000, Centre National de la Recherche Scientifique, Paris, France.
Paireau J; Mathematical Modelling of Infectious Diseases Unit, Unité Mixte de Recherche 2000, Centre National de la Recherche Scientifique, Paris, France.
Matheus S; Arbovirus National Reference Center, Institut Pasteur, Cayenne, French Guiana.; Environment and Infectious Risks Unit, Unité Mixte de Recherche 2000, Centre National de la Recherche Scientifique, Paris, France.
Enfissi A; Arbovirus National Reference Center, Institut Pasteur, Cayenne, French Guiana.
Fernandes-Pellerin S; Clinical Coordination of Translational Research Center, Institut Pasteur, Paris, France.
Djossou F; Infectious and Tropical Diseases Unit, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.
Linares S; Geographic Information and Knowledge Dissemination Unit, Direction de l'Environnement, de l'Aménagement et du Logement Guyane, Cayenne, French Guiana.
Carod JF; Medical Laboratory, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana.
Kazanji M; Epidemiology Unit, Cayenne, French Guiana.
Manuguerra JC; Environment and Infectious Risks Unit, Unité Mixte de Recherche 2000, Centre National de la Recherche Scientifique, Paris, France.
Cauchemez S; Mathematical Modelling of Infectious Diseases Unit, Unité Mixte de Recherche 2000, Centre National de la Recherche Scientifique, Paris, France.
Rousset D; Arbovirus National Reference Center, Institut Pasteur, Cayenne, French Guiana.
Źródło:: The Journal of infectious diseases [J Infect Dis] 2019 Nov 06; Vol. 220 (12), pp. 1915-1925.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
MeSH Terms:: Zika Virus*/immunology
Communicable Diseases, Emerging/*epidemiology
Communicable Diseases, Emerging/*virology
Zika Virus Infection/*epidemiology
Zika Virus Infection/*virology
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Communicable Diseases, Emerging/diagnosis ; Communicable Diseases, Emerging/immunology ; Cross-Sectional Studies ; Female ; French Guiana/epidemiology ; Geography, Medical ; Humans ; Male ; Middle Aged ; Population Surveillance ; Seroepidemiologic Studies ; Serologic Tests ; Young Adult ; Zika Virus Infection/diagnosis ; Zika Virus Infection/immunology
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Contributed Indexing:: Keywords: French Guiana; Zika virus; general population survey; seroprevalence study
Entry Date(s):: Date Created: 20190817 Date Completed: 20200522 Latest Revision: 20200522
Update Code:: 20240105
PubMed Central ID:: PMC6834069
DOI:: 10.1093/infdis/jiz396
PMID:: 31418012
: Czasopismo naukowe

Background: Since the identification of Zika virus (ZIKV) in Brazil in May 2015, the virus has spread throughout the Americas. However, ZIKV burden in the general population in affected countries remains unknown.
Methods: We conducted a general population survey in the different communities of French Guiana through individual interviews and serologic survey during June-October 2017. All serum samples were tested for anti-ZIKV immunoglobulin G antibodies using a recombinant antigen-based SGERPAxMap microsphere immunoassay, and some of them were further evaluated through anti-ZIKV microneutralization tests.
Results: The overall seroprevalence was estimated at 23.3% (95% confidence interval [CI], 20.9%-25.9%) among 2697 participants, varying from 0% to 45.6% according to municipalities. ZIKV circulated in a large majority of French Guiana but not in the most isolated forest areas. The proportion of reported symptomatic Zika infection was estimated at 25.5% (95% CI, 20.3%-31.4%) in individuals who tested positive for ZIKV.
Conclusions: This study described a large-scale representative ZIKV seroprevalence study in South America from the recent 2015-2016 Zika epidemic. Our findings reveal that the majority of the population remains susceptible to ZIKV, which could potentially allow future reintroductions of the virus.
(© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.)

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