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Tytuł pozycji:

Effects of non-tobacco flavors and nicotine on e-cigarette product appeal among young adult never, former, and current smokers.

Tytuł:
Effects of non-tobacco flavors and nicotine on e-cigarette product appeal among young adult never, former, and current smokers.
Autorzy:
Leventhal AM; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Psychology, University of Southern California, Los Angeles, CA, USA. Electronic address: .
Goldenson NI; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Barrington-Trimis JL; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Pang RD; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Kirkpatrick MG; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Źródło:
Drug and alcohol dependence [Drug Alcohol Depend] 2019 Oct 01; Vol. 203, pp. 99-106. Date of Electronic Publication: 2019 Aug 01.
Typ publikacji:
Journal Article; Randomized Controlled Trial
Język:
English
Imprint Name(s):
Publication: Limerick : Elsevier
Original Publication: Lausanne, Elsevier Sequoia.
MeSH Terms:
Consumer Behavior/*statistics & numerical data
Electronic Nicotine Delivery Systems/*statistics & numerical data
Flavoring Agents/*pharmacology
Nicotine/*pharmacology
Smokers/*psychology
Adult ; Double-Blind Method ; Female ; Humans ; Male ; Nicotiana ; Young Adult
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Grant Information:
P30 CA014089 United States CA NCI NIH HHS; P50 CA180905 United States CA NCI NIH HHS; U54 CA180905 United States CA NCI NIH HHS
Contributed Indexing:
Keywords: Flavors; Product appeal; Tobacco regulatory science; Young adults; e-Cigarettes
Substance Nomenclature:
0 (Flavoring Agents)
6M3C89ZY6R (Nicotine)
Entry Date(s):
Date Created: 20190822 Date Completed: 20200501 Latest Revision: 20231213
Update Code:
20240105
PubMed Central ID:
PMC7489757
DOI:
10.1016/j.drugalcdep.2019.05.020
PMID:
31434028
Czasopismo naukowe
Background: E-cigarette regulations targeting products that disproportionately appeal to never-smokers may optimize population health. This laboratory study of young adults tested whether differences in appeal between e-cigarettes with non-tobacco-flavored (vs. tobacco-flavored) and nicotine-containing (vs. nicotine-free) solutions varied by smoking history.
Methods: Current (N = 53), former (N = 25), and never (N = 22) cigarette smokers who vape (Mean[SD] age = 25.4[4.4] years) administered standardized e-cigarette doses varied by a Flavor (fruit, menthol, tobacco) × Nicotine (nicotine-containing [6 mg/mL], nicotine-free) within-subject double-blind design. Participants rated each dose's appeal (0-100 scale). Covariate-adjusted interactions tested whether smoking history moderated flavor and nicotine effects.
Results: Appeal was higher for fruit and menthol than tobacco flavors in each group. The fruit vs. tobacco appeal difference was greater in never smokers (fruit-tobacco estimate = 19.6) than current smokers (estimate = 12.1) but not former smokers (estimate = 12.6). The menthol vs. tobacco difference was greater in never smokers (menthol-tobacco estimate = 17.3) than former (estimate = 6.0) and current (estimate = 7.2) smokers. Appeal was lower for nicotine-containing than nicotine-free solutions in each group; this difference was greater in never smokers (nicotine-nicotine-free estimate = -17.3) than former (estimate = -7.0) and current (estimate = -10.6) smokers. Compared to tobacco flavors, nicotine's appeal-reducing effects were suppressed by fruit and menthol flavors in never smokers.
Conclusions: Higher appeal of non-tobacco-flavored (vs. tobacco-flavored) and lower appeal of nicotine-containing (vs. nicotine-free) e-cigarettes may be widespread in young adults but disproportionately amplified in never smokers. Non-tobacco flavors may suppress nicotine's appeal-lowering qualities in never smokers. The impact of regulating non-tobacco flavors in e-cigarettes may vary by smoking history.
(Copyright © 2019. Published by Elsevier B.V.)

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