Depersonalization- and derealization-like phenomena of epileptic origin.

Tytuł:: Depersonalization- and derealization-like phenomena of epileptic origin.
Autorzy:: Heydrich L; Laboratory of Cognitive Neuroscience, Brain-Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Department of Neurology, University Hospital Geneva, Geneva, Switzerland.; Core Lab, Psychosomatic Competence Center, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marillier G; Laboratory of Cognitive Neuroscience, Brain-Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Evans N; Laboratory of Cognitive Neuroscience, Brain-Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Seeck M; Department of Neurology, University Hospital Geneva, Geneva, Switzerland.
Blanke O; Laboratory of Cognitive Neuroscience, Brain-Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Department of Neurology, University Hospital Geneva, Geneva, Switzerland.; Center for Neuroprosthetics, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Źródło:: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2019 Sep; Vol. 6 (9), pp. 1739-1747. Date of Electronic Publication: 2019 Aug 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [Hoboken, NJ] : Wiley Periodicals, Inc on behalf of American Neurological Association, [2014]-
MeSH Terms:: Brain/*physiopathology
Depersonalization/*complications
Epilepsy/*complications
Adult ; Brain/diagnostic imaging ; Brain Mapping ; Depersonalization/diagnostic imaging ; Depersonalization/physiopathology ; Electroencephalography ; Epilepsy/diagnostic imaging ; Epilepsy/physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests ; Retrospective Studies
References:: Psychiatry Res. 2006 Dec 1;148(2-3):93-102. (PMID: 17085021)
Soc Cogn Affect Neurosci. 2007 Dec;2(4):303-12. (PMID: 18985136)
J Neurol. 2017 Jul;264(7):1532-1535. (PMID: 28667342)
Neuron. 2006 Apr 20;50(2):329-39. (PMID: 16630842)
Curr Opin Neurol. 2004 Apr;17(2):165-72. (PMID: 15021244)
Brain. 2013 Mar;136(Pt 3):790-803. (PMID: 23423672)
J Cogn Neurosci. 2007 Jul;19(7):1081-8. (PMID: 17583985)
Br J Psychiatry. 2008 Sep;193(3):222-8. (PMID: 18757982)
AMA Arch Neurol Psychiatry. 1959 Mar;81(3):269-84. (PMID: 13626278)
Neuroimage. 2006 May 15;31(1):440-57. (PMID: 16466680)
Neuroimage. 2007 Sep 1;37(3):866-75. (PMID: 17616402)
J Neurosurg. 2012 May;116(5):1042-8. (PMID: 22304450)
Science. 2009 May 8;324(5928):811-3. (PMID: 19423830)
J Nerv Ment Dis. 2007 Dec;195(12):983-8. (PMID: 18091191)
Curr Biol. 2011 Jul 12;21(13):1118-22. (PMID: 21683596)
Curr Biol. 2014 Nov 17;24(22):2681-6. (PMID: 25447995)
Am J Psychiatry. 2000 Nov;157(11):1782-8. (PMID: 11058475)
J Neurol. 2013 Jul;260(7):1880-8. (PMID: 23572346)
Psychiatry Res. 2011 Jul 30;188(2):264-8. (PMID: 21122925)
Nat Rev Neurosci. 2017 Apr;18(4):196-207. (PMID: 28251993)
Neuron. 2008 May 8;58(3):306-24. (PMID: 18466742)
Trends Cogn Sci. 2011 Feb;15(2):85-93. (PMID: 21167765)
Psychiatry Res. 2012 May 15;197(1-2):123-7. (PMID: 22414660)
Eur J Neurosci. 2011 May;33(10):1935-43. (PMID: 21395867)
Brain. 2007 Feb;130(Pt 2):574-84. (PMID: 17209228)
Epileptic Disord. 2007 Mar;9(1):20-31. (PMID: 17307708)
Trends Cogn Sci. 2009 Jan;13(1):7-13. (PMID: 19058991)
J Neurol Neurosurg Psychiatry. 2002 Apr;72(4):530-2. (PMID: 11909918)
Psychiatry Res. 2008 Jan 15;157(1-3):303-6. (PMID: 17959254)
Biol Psychiatry. 1998 Nov 1;44(9):898-908. (PMID: 9807645)
Neuron. 2015 Oct 7;88(1):145-66. (PMID: 26447578)
Brain Inj. 1993 Nov-Dec;7(6):507-13. (PMID: 8260954)
Am J Psychiatry. 2003 Oct;160(10):1740-7. (PMID: 14514481)
Conscious Cogn. 2008 Jun;17(2):523-34. (PMID: 18424080)
J Neurophysiol. 1997 May;77(5):2268-92. (PMID: 9163357)
Conscious Cogn. 2011 Mar;20(1):99-108. (PMID: 21087873)
J Neurophysiol. 2011 Feb;105(2):910-22. (PMID: 21148091)
J Neurol Neurosurg Psychiatry. 1993 Jul;56(7):788-92. (PMID: 8331355)
J Neuropsychiatry Clin Neurosci. 2002 Spring;14(2):141-54. (PMID: 11983788)
Science. 2004 Aug 6;305(5685):875-7. (PMID: 15232072)
Neuroimage. 2005 Jul 1;26(3):839-51. (PMID: 15955494)
Brain. 2004 Feb;127(Pt 2):243-58. (PMID: 14662516)
Conscious Cogn. 2010 Sep;19(3):702-10. (PMID: 20663690)
Ann Neurol. 1982 Aug;12(2):129-44. (PMID: 7125603)
J Neurol Neurosurg Psychiatry. 2015 Nov;86(11):1273-6. (PMID: 25587072)
Exp Brain Res. 2000 Nov;135(2):259-66. (PMID: 11131511)
Neuron. 2011 Apr 28;70(2):363-74. (PMID: 21521620)
Brain. 1978 Mar;101(1):83-117. (PMID: 638728)
Trends Cogn Sci. 2009 Oct;13(10):411-9. (PMID: 19748304)
Nat Rev Neurosci. 2012 Jul 18;13(8):556-71. (PMID: 22805909)
Grant Information:: International Fondation Roger de Spoelberch; International Fondation Bertarelli; International Cogito Foundation; 140332 International Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; 140338 International Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; 146633 International Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; 33CM30-124 089 International Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; 51AU40-125759 International Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Entry Date(s):: Date Created: 20190823 Date Completed: 20200512 Latest Revision: 20200512
Update Code:: 20240105
PubMed Central ID:: PMC6764488
DOI:: 10.1002/acn3.50870
PMID:: 31437864
: Czasopismo naukowe

Pełny tekst

Objective: Depersonalization refers to the sensation of being detached from one's body, often associated with feelings of loss of control over one's own body, actions, or thoughts. Derealization refers to the altered perception of one's surroundings that is experienced as unreal. Although usually reported by psychiatric patients suffering from depression or anxiety, single case reports and small case series have described depersonalization- and derealization-like symptoms in the context of epilepsy.
Methods: We investigated the brain mechanisms of ictal depersonalization- and derealization like symptoms by analyzing clinical and neuropsychological data as well as the epileptogenic zone based on a multimodal approach in a group of patients reporting depersonalization- (n = 9) and derealization-like symptoms (n = 7), from a single presurgical epilepsy center with focal epilepsy. We compared them with a group of control patients with experiential phenomena due to temporal lobe epilepsy (n = 28).
Results: We show that all patients with ictal depersonalization-like symptoms report altered self-identification with their body and mostly suffer from frontal lobe epilepsy with the epileptogenic zone in the dorsal premotor cortex, while patients with derealization-like symptoms suffer from temporal lobe epilepsy. This finding is supported by post-ictal neuropsychological deficits, showing that depersonalization-like symptoms were significantly more often associated with frontal lobe dysfunction as compared to the control patients and patients with derealization-like symptoms.
Conclusion: We argue that depersonalization of epileptic origin constitutes a distinct disorder due to frontal lobe epilepsy. We discuss these findings with respect to earlier accounts of depersonalization and the recent concept of bodily self-consciousness.
(© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.)

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja