Administration of ginger and/or thyme has ameliorative effects on liver and kidney functions of V-line rabbits: Histological and biochemical studies.
Abdel-Gabbar M; Biochemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Ahmed RR; Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Kandeil MA; Biochemistry Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt.
Mohamed AEH; Animal Production Research Institute, Agricultural Research Center, Giza, Egypt.
Ali SM; Animal Production Research Institute, Agricultural Research Center, Giza, Egypt.
Journal of animal physiology and animal nutrition [J Anim Physiol Anim Nutr (Berl)] 2019 Nov; Vol. 103 (6), pp. 1758-1767. Date of Electronic Publication: 2019 Aug 22.
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
Imprint Name(s) :
Original Publication: [Berlin] : Blackwell Science, c2001-
MeSH Terms :
Animal Feed/analysis ; Animal Nutritional Physiological Phenomena ; Animals ; Antioxidants/metabolism ; Diet/veterinary ; Kidney/anatomy & histology ; Lipid Metabolism/drug effects ; Liver/anatomy & histology ; Male ; Oxidative Stress
Abd-Allah, G. A., El-Bakry, K. A., Bahnasawy, M. H., & El-Khodary, E. R. (2016). Protective effects of curcumin and ginger on liver cirrhosis induced by carbon tetrachloride in rats. International Journal of Pharmacology, 12(4), 361-369. https://doi.org/10.3923/ijp.2016.361.369.
Abdulkarimi, R., Daneshyar, M., & Aghazadeh, A. (2011). Thyme (Thymus vulgaris) extract consumption darkens liver, lowers blood cholesterol, proportional liver and abdominal fat weights in broiler chickens. Italian Journal of Animal Science, 10(20), 101-105.
Abu-Raghif, A. R., Qasim, B. J., Abady, A. H., & Sahib, H. B. (2015). Effects of aqueous thyme extract against cisplatin induced nephrotoxicity in rabbits. International Journal of Pharmaceutical Sciences Review and Research, 30(1), 190-194.
Ademola, S. G., Farimu, G. O., & Babatunde, G. M. (2009). Serum lipid, growth and haematological parameters of broilers fed garlic, ginger and their mixtures. World Journal of Agricultural Sciences, 5(1), 99-104.
Al Khdri, A. M. A. (2013). Effect of ginger (Zingiber officinale) and thyme (Thymus vulgaris) dietary supplementation on productive and immunological performance of broiler. M. Sc. Thesis, School of Animal Production, Faculty of Agriculture and Forestry, University of Duhok.
Ansari, K. M. H., Karimipour, M. B., Salami, S. A., & Shirpoor, A. C. (2008). The effect of ginger (Zingiber officinale) on oxidative stress status in the small intestine of diabetic rats. International Journal of Endocrinology and Metabolism, 3, 144-150.
Assiri, A. M. A., Elbanna, K., Abulreesh, H. H., & Ramadan, M. F. (2016). Bioactive compounds of cold-pressed thyme (Thymus vulgaris) oil with antioxidant and antimicrobial properties. Journal of Oleo Science, 65, 629-640.
Atef, M. A., & Talal, A. Z. (2007). Modulatory effects of ginger and clove oils on physiological responses in streptozotocin-induced diabetic rats. International Journal of Pharmacology, 3(1), 34-40. https://doi.org/10.3923/ijp.2007.34.40.
Attia, Y. A., Bakhashwain, A. A., & Bertu, N. K. (2017). Thyme oil (Thyme vulgaris L.) as a natural growth promoter for broiler chickens reared under hot climate. Italian Journal of Animal Science, 16, 275-282.
Baranauskiene, R., Venskutonis, P. R., Viskelis, P., & Dambrauskiene, E. (2003). Influence of nitrogen fertilizers on the yield and composition of thyme (Thymus vulgaris). Journal of Agricultural and Food Chemistry, 51(26), 7751-7758.
Barazesh, H. B., Pour, M. B. P., Salari, S. S., & Abadi, T. M. (2013). The effect of ginger powder on performance, carcass characteristics and blood parameters of broilers. International Journal of Advanced Biological and Biomedical Research, 1(12), 1645-1651.
Bhandari, U., Kanojia, R., & Pillai, K. K. (2005). Effect of ethanolic extract of Zingiber officinale on dyslipidemia in diabetic rats. Journal of Ethnopharmacology, 97, 227-230.
Bovera, F., Piccolo, G., Gasco, L., Marono, S., Loponte, R., Vassalotti, G., … Nizza, A. (2015). Yellow mealworm larvae (Tenebrio molitor, L.) as a possible alternative to soybean meal in broiler diets. British Poultry Science, 56, 569-575.
Bozkurt, M., Küçükyilmaz, K., Pamukçu, M., Çabuk, M., Alçiçek, A., & Çatli, A. U. (2012). Long-term effects of dietary supplementation with an essential oil mixture on the growth and laying performance of two layer strains. Italian Journal of Animal Science, 11(5), 23-27. https://doi.org/10.4081/ijas.2012.e5.
Cross, D. E., Sovboda, K., McDevitt, R. M., & Acamovic, T. (2003). The effect of herbs and their associated essential oils on performance, dietary digestibility and gut microflora in chickens from 7 to 28 days of age. British Poultry Science, 48, 496-506. https://doi.org/10.1080/00071660701463221.
Dauqan, E. M. A., & Abdullah, A. (2017). Medicinal and functional values of thyme (Thymus vulgaris L.) herb. Journal of Applied Biology and Biotechnology, 5(02), 017-022.
EL-Sayed, S. M., & Moustafa, R. A. (2016). Effect of combined administration of ginger and cinnamon on high fat diet induced hyperlipidemia in rats. Journal of Pharmaceutical, Chemical and Biological Sciences, 3(4), 561-572.
Elwan, H. A., Elnesr, S. S., Mohany, M., & Al-Rejaie, S. S. (2019). The effects of dietary tomato powder (Solanum lycopersicum L.) supplementation on the haematological, immunological, serum biochemical and antioxidant parameters of growing rabbits. Journal of Animal Physiology and Animal Nutrition, 103(2), 534-546.
Farag, R. S., Badei, A. Z. M. A., Hewedi, F. M., & El-Baroty, G. S. A. (1989). Antioxidant activity of some spice essential oils on linoleic acid oxidation in aqueous media. Journal of the American Oil Chemists' Society, 66(6), 792-799. https://doi.org/10.1007/BF02653670.
Gabr, S. A., Alghadir, A. H., & Ghoniemc, G. A. (2019). Biological activities of ginger against cadmium-induced renal toxicity. Saudi Journal of Biological Sciences, 26(2), 382-389. https://doi.org/10.1016/j.sjbs.2017.08.008.
George, O. S., Kaegon, S. G., & Igbokwe, A. A. (2015). Feed additive effects of graded levels of ginger (Zingiber officinale) on serum metabolites of broilers. IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS), 8(3), 59-62.
Ghayur, M. N., & Gilani, A. H. (2005). Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Digestive Diseases and Sciences, 50, 1889-1897.
Haniadka, R., Saxena, A., Shivashankara, A. R., Fayad, R., Palatty, P. L., Nazreth, N., … Baliga, M. S. (2013). Ginger protects the liver against the toxic effects of xenobiotic compounds: Preclinical observations. Journal of Nutrition and Food Sciences, 3(5), 1-7.
Hasan, M. A. A. (2015). A histopathological study and antioxidant effect of ginger to diminishing poisoning lead acetate-induced hepatopathy in rabbits for three months. Journal of Biology, Agriculture and Healthcare, 5(4), 150-158.
Ibtisham, F., Nawab, A., Li, G., Xiao, M., An, L., & Naseer, G. (2018). Effect of nutrition on reproductive efficiency of dairy animals. Medycyna Weterynaryjna, 74(6), 356-361. https://doi.org/10.21521/mw.6025.
Ibtisham, F., Nawab, A., Niu, Y., Wang, Z., Wu, J., Xiao, M., & LiLong, A. N. (2019). The effect of ginger powder and Chinese herbal medicine on production performance, serum metabolites and antioxidant status of laying hens under heat-stress condition. Journal of Thermal Biology, 81, 20-24. https://doi.org/10.1016/j.jtherbio.2019.02.002.
Khaki, A., Fathiazad, F., Nouri, M., Khaki, A. A., Chelar, C., Ozanci, C., … Hamadeh, M. (2009). The effects of ginger on spermatogenesis and sperm parameters of rat. Iranian Journal of Reproductive Medicine, 7, 7-12.
Kikuzaki, H., & Nakatani, N. (2006). Antioxidant effects of some ginger constituents. Journal of Food Science, 58, 1407-1410. https://doi.org/10.1111/j.1365-2621.1993.tb06194.x.
Kovács, M., Tuboly, T., Mézes, M., Balogh, K., Gerencsér, Z., Matics, Z., … Dalle-Zotte, A. (2016). Effect of dietary supplementation of spirulina (Arthrospira platensis) and thyme (Thymus vulgaris) on serum biochemistry, immune response and antioxidant status of rabbits. Annals of Animal Science, 16(1), 181-195. https://doi.org/10.1515/aoas-2015-0059.
Liu, N., Huo, G., Zhang, L., & Zhang, X. (2003). Effect of Zingiber officinale Rosc on lipid peroxidation in hyperlipidemic rats. Wei Sheng Yan Jiu, 32, 22-23.
Liu, Q., Yuan, B., Lo, K. A., Patterson, H. C., Sun, Y., & Lodish, H. F. (2012). Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism. Proceedings of the National Academy of Sciences of the United States of America, 109, 14568-14573. https://doi.org/10.1073/pnas.1211611109.
Lopes-Virella, M. F., Stone, P., Ellis, S., & Colwell, J. A. (1977). Cholesterol determination in high-density lipoproteins separated by three different methods. Clinical Chemistry, 23, 882-884.
Mansoub, N. H., & Nezhady, M. A. M. (2011). The effect of using thyme, garlic, nettle on performance, carcass quality and blood parameters. Annals of Applied Biology, 2, 315-320.
Masuda, Y., Kikuzaki, H., Hisamoto, M., & Nikatani, N. (2004). Antioxidant properties of gingerol related compounds from ginger. BioFactors, 21, 293-296. https://doi.org/10.1002/biof.552210157.
Nanyonga, S. K., Opoku, A., Lewu, F. B., Oyedeji, A. O., & Singh, M. (2013). Chemical composition, antioxidant activity and cytotoxicity of the essential oils of the leaves and stem of Tarchonanthus camphoratus. African Journal of Pharmacy and Pharmacology, 7(7), 360-367. https://doi.org/10.5897/AJPP12.600.
Salem, A. A. (2015). Effect of feeding on olive oil and thyme on pregnancy and lactation periods. International Journal of Nutrition and Food Sciences, 4(1), 19-28. https://doi.org/10.11648/j.ijnfs.20150401.14.
Sanjay, P., Akhani, S., Vishwakarma, L., & Goyal, R. K. (2004). Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. Journal of Pharmacy and Pharmacology, 56(1), 101.
Shati, A. A., & Elsaid, F. G. (2009). Effects of water extracts of thyme (Thymus vulgaris) and ginger (Zingiber officinale Roscoe) on alcohol abuse. Food and Chemical Toxicology, 47, 1945-1949. https://doi.org/10.1016/j.fct.2009.05.007.
Swayeh, N. H., Abu-Raghif, A. R., Qasim, B. J., & Sahib, H. B. (2014). The protective effects of Thymus vulgaris aqueous extract against methotrexate induced hepatic toxicity in rabbits. International Journal of Pharmaceutical Sciences Review and Research, 29(2), 187-193.
Tacke, F., Luedde, T., & Trautwein, C. (2009). Inflammatory pathways in liver homeostasis and liver injury. Clinical Reviews in Allergy and Immunology, 36, 4-12. https://doi.org/10.1007/s12016-008-8091-0.
Yang, C., Chowdhury, M. A. K., Hou, Y., & Gong, J. (2015). Phytogenic compounds as alternatives to in-feed antibiotics: Potentials and challenges in application. Pathogens, 4, 137-156. https://doi.org/10.3390/pathogens4010137.
Young, D. S. (2000). Effects of drugs on clinical laboratory tests (5th ed.). Washington, DC: AACC Press.
Yu, Y. D., Kim, K. H., Lee, S. G., Choi, S. Y., Kim, Y. C., Byun, K. S., … Choi, D. H. (2011). Hepatic differentiation from human embryonic stem cells using stromal cells. Journal of Surgical Research, 170, e253-e261. https://doi.org/10.1016/j.jss.2011.06.032.
Zancan, K. C., Marques, M. O., Petenate, A. J., & Meireles, M. A. (2002). Extraction of ginger (Zingiber officinale Roscoe) oleoresin with CO2 and co-solvents: A study of the antioxidant action of the extracts. Journal of Supercritical Fluids, 24(1), 57-67. https://doi.org/10.1016/S0896-8446(02)00013-X.
Contributed Indexing :
Keywords: antioxidant; ginger; kidney; liver; rabbits; thyme
Substance Nomenclature :
Entry Date(s) :
Date Created: 20190824 Date Completed: 20200423 Latest Revision: 20200423
Update Code :
This study was conducted to evaluate the effect of Zingiber officinale and Thymus vulgaris aqueous extracts as a natural antioxidant on liver and kidney functions and antioxidant status of growing rabbits. A total of 24 V-line male rabbits, 3 months old, 1.465 ± 0.12 kg average body weight (BW) were used in a complete randomized design. The rabbits were weighed individually and assigned randomly to four groups (6 animals/each). The first group (G1) was taken fresh water and served as control, rabbits of the second group (G2) were taken 100 mg/kg BW in drinking water of the Z. officinale aqueous extract daily. The third group (G3) was taken 50 mg/kg BW in drinking water of the T. vulgaris aqueous extract daily and the fourth group (G4) was taken 100 mg/kg BW of the Z. officinale aqueous extract plus 50 mg/kg BW of the T. vulgaris aqueous extract in drinking water daily. The oral administration of ginger and/or thyme aqueous extracts increased (p < .001) serum protein profile compared with control group. Moreover, results of group 2 showed significant (p < .001) decrease in cholesterol, triglyceride and very low-density lipoprotein cholesterol compared with group 3 and 4. Serum urea, uric acid and creatinine levels were significantly (p < .001) decreased in treated groups compared with control group. Oral administration of ginger and/or thyme aqueous extracts to growing rabbits increased (p < .001) total antioxidant capacity and glutathione content and the activity of superoxide dismutase, catalase and glutathione-S-transferase compared with the control group. In conclusion, the current study showed that oral administration of ginger and thyme aqueous extracts to growing rabbits showed no adverse effects on liver and kidney function parameters, histological structures and improved antioxidant status.
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