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Tytuł pozycji:

Association of Concurrent Changes in Metabolic Health and Weight on Cardiovascular Disease Risk: A Nationally Representative Cohort Study.

Tytuł:
Association of Concurrent Changes in Metabolic Health and Weight on Cardiovascular Disease Risk: A Nationally Representative Cohort Study.
Autorzy:
Bae YS; Department of Family Medicine Seoul National University Hospital Seoul Republic of Korea.; Office of Hospital Information Seoul National University Hospital Seoul Republic of Korea.
Choi S; Department of Biomedical Sciences Seoul National University Graduate School Seoul Republic of Korea.
Lee K; Department of Family Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea.
Son JS; Department of Family Medicine Seoul National University Hospital Seoul Republic of Korea.
Lee H; Department of Family Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea.
Cho MH; Samsung C&T Medical Clinic Kangbuk Samsung Hospital Seoul Republic of Korea.
Koo HY; Department of Family Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea.
Cho IY; Department of Family Medicine Samsung Medical Center Seoul Republic of Korea.
Chang J; Department of Biomedical Sciences Seoul National University Graduate School Seoul Republic of Korea.
Kim K; Department of Biomedical Sciences Seoul National University Graduate School Seoul Republic of Korea.
Kim SM; Department of Biomedical Sciences Seoul National University Graduate School Seoul Republic of Korea.
Park SM; Department of Family Medicine Seoul National University Hospital Seoul Republic of Korea.; Department of Biomedical Sciences Seoul National University Graduate School Seoul Republic of Korea.
Źródło:
Journal of the American Heart Association [J Am Heart Assoc] 2019 Sep 03; Vol. 8 (17), pp. e011825. Date of Electronic Publication: 2019 Aug 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: Oxford : Wiley-Blackwell
MeSH Terms:
Body Mass Index*
Energy Metabolism*
Cardiovascular Diseases/*epidemiology
Hypercholesterolemia/*epidemiology
Hyperglycemia/*epidemiology
Hypertension/*epidemiology
Obesity, Metabolically Benign/*epidemiology
Biomarkers/blood ; Blood Glucose/analysis ; Blood Pressure ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Cholesterol/blood ; Databases, Factual ; Female ; Health Status ; Health Surveys ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/therapy ; Hyperglycemia/blood ; Hyperglycemia/therapy ; Hypertension/physiopathology ; Hypertension/therapy ; Male ; Middle Aged ; Obesity, Metabolically Benign/blood ; Obesity, Metabolically Benign/physiopathology ; Obesity, Metabolically Benign/therapy ; Prognosis ; Republic of Korea/epidemiology ; Risk Assessment ; Risk Factors ; Time Factors ; Weight Gain ; Weight Loss
References:
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Contributed Indexing:
Keywords: cardiovascular disease; high blood pressure; hypercholesterolemia; hyperglycemia; hypertension; obesity
Substance Nomenclature:
0 (Biomarkers)
0 (Blood Glucose)
97C5T2UQ7J (Cholesterol)
Entry Date(s):
Date Created: 20190828 Date Completed: 20200914 Latest Revision: 20210110
Update Code:
20240104
PubMed Central ID:
PMC6755827
DOI:
10.1161/JAHA.118.011825
PMID:
31451053
Czasopismo naukowe
Background The combined effect of transitions of metabolic health and weight on cardiovascular disease (CVD) remains unclear. We aimed to examine the association of concurrent changes of metabolic health and weight on CVD over time. Methods and Results The study population consisted of 205 394 from the Korean National Health Insurance Service. Metabolic health was determined by fasting serum glucose, total cholesterol, and blood pressure levels, while obesity was determined by body mass index. All participants were divided into either metabolically healthy nonobese (MHNO), metabolically healthy obese, metabolically unhealthy nonobese, or metabolically unhealthy obese for each of the first (2002-2003) and second (2004-2005) health screening periods, after which participants were followed-up for CVD from 2006 to 2015. Cox proportional hazards regression was used to determine adjusted hazard ratios (aHRs) and 95% CIs. Among initial MHNO participants, those who became metabolically healthy obese (aHR, 1.25; 95% CI, 1.10-1.41), metabolically unhealthy nonobese (aHR, 1.23; 95% CI, 1.15-1.31), and metabolically unhealthy obese (aHR, 1.34; 95% CI, 1.12-1.61) had elevated risk for CVD compared with those who remained MHNO. Conversely, improving metabolic health and obesity were associated with reduced CVD risk among initially metabolically unhealthy nonobese to secondary MHNO (aHR, 0.79; 95% CI, 0.73-0.84), metabolically unhealthy obese to MHNO (aHR, 0.68; 95% CI, 0.58-0.81), and metabolically unhealthy obese to metabolically healthy obese (aHR, 0.73; 95% CI, 0.66-0.80) participants. Conclusions Changes toward metabolically unhealthy or obese states resulted in increased CVD risk. Improving metabolic health along with reducing weight may lead to decreased risk of CVD.

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