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Tytuł pozycji:

Possible prophylactic effect of omega-3 fatty acids on cadmium-induced neurotoxicity in rats' brains.

Tytuł:
Possible prophylactic effect of omega-3 fatty acids on cadmium-induced neurotoxicity in rats' brains.
Autorzy:
Alnahdi HS; Department of Biochemistry, Faculty of Science -Alfaisaliah, King Abdulaziz University, PO Box 50212, Jeddah, 21523, Saudi Arabia.; Department of Biochemistry, Faculty of Science -Alfaisaliah, University of Jeddah, PO Box 50212, Jeddah, 21523, Saudi Arabia.
Sharaf IA; Department of Biochemistry, Faculty of Science -Alfaisaliah, King Abdulaziz University, PO Box 50212, Jeddah, 21523, Saudi Arabia. .; Department of Biochemistry, Faculty of Science -Alfaisaliah, University of Jeddah, PO Box 50212, Jeddah, 21523, Saudi Arabia. .
Źródło:
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2019 Oct; Vol. 26 (30), pp. 31254-31262. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
MeSH Terms:
Cadmium/*toxicity
Fatty Acids, Omega-3/*pharmacology
Neuroprotective Agents/*pharmacology
Neurotoxicity Syndromes/*pathology
Neurotoxicity Syndromes/*prevention & control
Animals ; Antioxidants/pharmacology ; Brain/drug effects ; Brain/pathology ; Cadmium Chloride/toxicity ; Cadmium Poisoning/prevention & control ; Dietary Supplements ; Enzymes/metabolism ; Lipid Peroxidation/drug effects ; Male ; Neurons/drug effects ; Neurons/metabolism ; Neurotoxicity Syndromes/etiology ; Rats
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Grant Information:
G:82-363-1439 Deanship of Scientific Research at King Abdulaziz University
Contributed Indexing:
Keywords: Biochemical changes; Cadmium; Neurodegenerative disorders; Neurotoxicity; Omega-3 fatty acid; Prophylactic effect
Substance Nomenclature:
0 (Antioxidants)
0 (Enzymes)
0 (Fatty Acids, Omega-3)
0 (Neuroprotective Agents)
00BH33GNGH (Cadmium)
J6K4F9V3BA (Cadmium Chloride)
Entry Date(s):
Date Created: 20190831 Date Completed: 20200107 Latest Revision: 20210110
Update Code:
20240104
PubMed Central ID:
PMC6828832
DOI:
10.1007/s11356-019-06259-8
PMID:
31468353
Czasopismo naukowe
Cadmium (Cd) has long been noted to induce neurodegenerative disorders. Therefore, this study aimed to assess the toxicological impact of Cd on rat brains and evaluate the possible ameliorative impact of omega-3 fatty acids as a protective agent of nervous system. Rats were divided into four groups: group I supplemented orally with saline; group II intoxicated with CdCl 2 (5 mg/kg b.w. orally), and groups III and VI supplemented with omega-3 (100 mg/kg b.w. orally) simultaneously or before CdCl 2 administration, respectively. Cd intoxication induced biochemical and histopathological disturbances in treated rats. Omega-3 fatty acid considerably improved the Cd-associated biochemical changes, reduced the elevation of lipid peroxidation, and normalized the Cd impact on the levels of superoxide dismutase, catalase, glutathione-S-transferases, 8-hydroxydeoxyguanosine, heatshock protein70, nuclear factor-κB, and interferon-γ as well as of neuronal enzymes such as acetylecholinesterase and monoamine oxidase within the brains of treated rats. Additionally, histological findings supported the results that Cd treatment-induced neurodegenerative changes and that polyunsaturated fatty acids act as antioxidants and neuroprotective agents against Cd toxicity. Co-treatment with omega-3 fatty acid was more beneficial than pretreatment. Thus, omega-3 fatty acid should be included in diet to prevent or suppress neurodegenerative disorders caused by continuous exposure to Cd.

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