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Tytuł pozycji:

Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior.

Tytuł:
Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior.
Autorzy:
Wang H; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Chen J; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Xu X; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Sun WJ; Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China.
Chen X; Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China.
Zhao F; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Luo MH; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Liu C; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Guo Y; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Xie W; Department of Psychology, Anhui Mental Health Center, Hefei, China.
Zhong H; Department of Psychology, Anhui Mental Health Center, Hefei, China.
Bai T; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Tian Y; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Mao Y; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.; Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Ye C; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Tao W; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Li J; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Farzinpour Z; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Li J; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Zhou JN; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Wang K; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
He J; Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China.
Chen L; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Zhang Z; Hefei National Laboratory for Physical Sciences at the Microscale, Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Źródło:
PLoS biology [PLoS Biol] 2019 Aug 30; Vol. 17 (8), pp. e3000417. Date of Electronic Publication: 2019 Aug 30 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: San Francisco, CA : Public Library of Science, [2003]-
MeSH Terms:
Auditory Cortex/*physiology
Escape Reaction/*physiology
Periaqueductal Gray/*metabolism
Animals ; Auditory Cortex/metabolism ; Auditory Perception/physiology ; Behavior, Animal/physiology ; Defense Mechanisms ; Excitatory Amino Acids/physiology ; GABAergic Neurons/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways/physiology ; Optogenetics/methods ; Periaqueductal Gray/physiology ; Sound
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Substance Nomenclature:
0 (Excitatory Amino Acids)
Entry Date(s):
Date Created: 20190831 Date Completed: 20200227 Latest Revision: 20200309
Update Code:
20240104
PubMed Central ID:
PMC6742420
DOI:
10.1371/journal.pbio.3000417
PMID:
31469831
Czasopismo naukowe
Threatening sounds can elicit a series of defensive behavioral reactions in animals for survival, but the underlying neural substrates are not fully understood. Here, we demonstrate a previously unexplored neural pathway in mice that projects directly from the auditory cortex (ACx) to the lateral periaqueductal gray (lPAG) and controls noise-evoked defensive behaviors. Electrophysiological recordings showed that the lPAG could be excited by a loud noise that induced an escape-like behavior. Trans-synaptic viral tracing showed that a great number of glutamatergic neurons, rather than GABAergic neurons, in the lPAG were directly innervated by those in layer V of the ACx. Activation of this pathway by optogenetic manipulations produced a behavior in mice that mimicked the noise-evoked escape, whereas inhibition of the pathway reduced this behavior. Therefore, our newly identified descending pathway is a novel neural substrate for noise-evoked escape and is involved in controlling the threat-related behavior.
Competing Interests: The authors have declared that no competing interests exist.
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