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Tytuł pozycji:

Exploring the link between tumour metabolism and succinate dehydrogenase deficiency: A 18 F-FDOPA PET/CT study in head and neck paragangliomas.

Tytuł:
Exploring the link between tumour metabolism and succinate dehydrogenase deficiency: A F-FDOPA PET/CT study in head and neck paragangliomas.
Autorzy:
Reichert T; Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.
Fakhry N; Department of Head and Neck Surgery, Conception Hospital, Aix-Marseille Univ, Marseille, France.
Lavieille JP; Department of Head and Neck Surgery, Conception Hospital, Aix-Marseille Univ, Marseille, France.
Amodru V; Department of Endocrinology, Conception University Hospital, Aix-Marseille University, Marseille, France.
Sebag F; Department of Endocrine Surgery, Conception University Hospital, Aix-Marseille University, Marseille, France.
Romanet P; Laboratory of Molecular Biology, Conception Hospital & CNRS, CRN2M UMR 7286, Aix-Marseille University, Marseille, France.
Loundou A; Department of Public Health, EA3279 Self-perceived Health Assessment Research Unit, Aix-Marseille University, Marseille, France.
Castinetti F; Department of Endocrinology, Conception University Hospital, Aix-Marseille University, Marseille, France.
Pacak K; Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD, USA.
Montava M; Department of Head and Neck Surgery, Conception Hospital, Aix-Marseille Univ, Marseille, France.
Taïeb D; Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.
Źródło:
Clinical endocrinology [Clin Endocrinol (Oxf)] 2019 Dec; Vol. 91 (6), pp. 879-884. Date of Electronic Publication: 2019 Oct 01.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: <2003->: Oxford : Blackwell Publishing
Original Publication: Oxford, Blackwell Scientific Publications.
MeSH Terms:
Head and Neck Neoplasms/*diagnostic imaging
Head and Neck Neoplasms/*enzymology
Paraganglioma/*diagnostic imaging
Paraganglioma/*enzymology
Positron Emission Tomography Computed Tomography/*methods
Succinate Dehydrogenase/*deficiency
Adult ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Mutation ; Radionuclide Imaging ; Retrospective Studies ; Succinate Dehydrogenase/metabolism
References:
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Grant Information:
Z99 HD999999 United States ImNIH Intramural NIH HHS; ZIA HD008735 United States ImNIH Intramural NIH HHS
Contributed Indexing:
Keywords: 18F-FDOPA; genetics; paragangliomas; radionuclide imaging; succinate dehydrogenase
Substance Nomenclature:
EC 1.3.99.1 (Succinate Dehydrogenase)
Entry Date(s):
Date Created: 20190904 Date Completed: 20200914 Latest Revision: 20221005
Update Code:
20240105
PubMed Central ID:
PMC7446860
DOI:
10.1111/cen.14086
PMID:
31479526
Czasopismo naukowe
Objectives: Nuclear imaging findings by virtue of phenotyping disease heavily depend on genetic background, metabolites, cell membrane specific targets and signalling pathways. PPGL related to succinate dehydrogenase subunits mutations (SDHx mutations) are less differentiated than other subgroups and therefore may lack to concentrate 18 F-FDOPA, a precursor of catecholamines biosynthesis. However, this 18 F-FDOPA negative phenotype has been reported mostly in SDHx-PPGL of sympathetic origin, suggesting that both genotype status and location (from sympathetic vs parasympathetic paraganglia; adrenal vs extra-adrenal) could influence 18 F-FDOPA uptake. The aim of this study was to test if SDHx drives 18 F-FDOPA uptake in presence of normal epinephrine/norepinephrine concentrations.
Design: Retrospective study PATIENTS: A cohort of 86 head and neck PPGL patients (including three metastatic) with normal metanephrines underwent 18 F-FDOPA PET/CT. The relationships between 18 F-FDOPA uptake and tumour genotype were evaluated.
Results: In nonmetastatic HNPGL (50 non-SDHx/33 SDHx), no significant difference was observed between these two groups for SUVmax (P = .256), SUVmean (P = .188), MTV 42% (P = .596) and total lesion uptake (P = .144). Metastatic HNPGL also had high elevated uptake values.
Conclusions: Our results suggest that SDH deficiency or metastatic behaviour have no influence on 18 F-FDOPA uptake in HNPGL probably due to their very-well differentiation status, even at metastatic stage. The potential prognosticator value of 18 F-FDOPA uptake would need to be further explored in the setting of metastatic PPGL of sympathetic origin.
(© 2019 John Wiley & Sons Ltd.)

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