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Tytuł:
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In vitro bactericidal activity of amoxicillin combined with different cephalosporins against endocarditis-associated Enterococcus faecalis clinical isolates.
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Autorzy:
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Peiffer-Smadja N; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Assistance-Publique Hôpitaux de Paris, Paris, France.; Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France.
Guillotel E; CHU de Rennes, Service de Bactériologie-Hygiène hospitalière, Rennes, France.
Luque-Paz D; CHU de Rennes, Service de Bactériologie-Hygiène hospitalière, Rennes, France.
Maataoui N; Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France.; Laboratoire de Bactériologie, Hôpital Bichat-Claude Bernard, Assistance-Publique Hôpitaux de Paris, Paris, France.
Lescure FX; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Assistance-Publique Hôpitaux de Paris, Paris, France.; Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France.
Cattoir V; CHU de Rennes, Service de Bactériologie-Hygiène hospitalière, Rennes, France.; CNR de la Résistance aux Antibiotiques (laboratoire associé 'Entérocoques'), Rennes, France.; Unité Inserm U1230, Université de Rennes 1, Rennes, France.
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Źródło:
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The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2019 Dec 01; Vol. 74 (12), pp. 3511-3514.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 1997- : London : Oxford University Press
Original Publication: London, New York, Academic Press.
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MeSH Terms:
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Amoxicillin/*pharmacology
Anti-Bacterial Agents/*pharmacology
Cephalosporins/*pharmacology
Enterococcus faecalis/*drug effects
Drug Synergism ; Microbial Sensitivity Tests
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
0 (Cephalosporins)
804826J2HU (Amoxicillin)
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Entry Date(s):
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Date Created: 20190910 Date Completed: 20200925 Latest Revision: 20200925
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Update Code:
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20240105
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DOI:
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10.1093/jac/dkz388
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PMID:
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31495901
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Background: The combination of amoxicillin with cefazolin could be an interesting regimen for the empirical therapy of severe infective endocarditis, but its activity against enterococci is unknown.
Objectives: To evaluate in vitro the bactericidal activity of the combination of amoxicillin with different cephalosporins including cefazolin.
Methods: Combinations of amoxicillin (at MIC×¼) with cefazolin, cefotaxime, ceftriaxone, cefepime, ceftaroline or ceftobiprole (at the mean free plasma concentration) were studied using time-kill experiments for 10 endocarditis-associated Enterococcus faecalis strains and 2 reference strains.
Results: The combinations amoxicillin/cefazolin, amoxicillin/cefotaxime, amoxicillin/ceftriaxone and amoxicillin/cefepime were synergistic at 12 and 24 h against 12/12 strains and amoxicillin/ceftobiprole and amoxicillin/ceftaroline against 10/12 strains. The combination amoxicillin/cefepime was bactericidal at 24 h against 9/12 strains, the combination amoxicillin/cefazolin against 8/12 strains, the combinations amoxicillin/ceftaroline, amoxicillin/cefotaxime and amoxicillin/ceftobiprole against 7/12 strains and the combination amoxicillin/ceftriaxone against 6/12 strains.
Conclusions: The combination amoxicillin/cefazolin is as synergistic and bactericidal in vitro as amoxicillin/cefotaxime or amoxicillin/ceftriaxone against E. faecalis.
(© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
