Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation.

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Tytuł:: Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation.
Autorzy:: Leermakers PA; Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Kneppers AEM; Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Schols AMWJ; Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Kelders MCJM; Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
de Theije CC; Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Verdijk LB; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
van Loon LJC; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Langen RCJ; Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Gosker HR; Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Źródło:: Muscle & nerve [Muscle Nerve] 2019 Dec; Vol. 60 (6), pp. 769-778. Date of Electronic Publication: 2019 Oct 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: <2005-> : Hoboken, NJ : John Wiley & Sons
Original Publication: New York, NY : John Wiley & Sons
MeSH Terms:: Hindlimb Suspension*
Organelle Biogenesis*
Mitochondria, Muscle/*metabolism
Mitophagy/*genetics
Muscle, Skeletal/*metabolism
Adolescent ; Adult ; Animals ; Casts, Surgical ; Gene Expression ; Humans ; Immobilization ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria, Muscle/pathology ; Mitophagy/physiology ; Muscle, Skeletal/pathology ; Quadriceps Muscle/metabolism ; Quadriceps Muscle/pathology ; Weight-Bearing ; Young Adult
References:: EMBO Rep. 2014 May;15(5):566-75. (PMID: 24671035)
Biochim Biophys Acta. 2013 Jan;1833(1):205-12. (PMID: 22406072)
J Gerontol A Biol Sci Med Sci. 2014 Aug;69(8):1040-8. (PMID: 24526667)
J Physiol. 2015 Jun 15;593(12):2547-9. (PMID: 26095019)
Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. (PMID: 25840011)
Nat Cell Biol. 2012 Jan 22;14(2):177-85. (PMID: 22267086)
Autophagy. 2016;12(4):689-702. (PMID: 27050458)
J Physiol. 2015 Apr 15;593(8):1981-95. (PMID: 25565653)
Hum Mol Genet. 2015 May 1;24(9):2528-38. (PMID: 25612572)
Trends Endocrinol Metab. 2015 Jun;26(6):305-14. (PMID: 25934582)
Biogerontology. 2012 Dec;13(6):621-31. (PMID: 23187721)
PLoS One. 2010 May 24;5(5):e10778. (PMID: 20520725)
Protein Cell. 2017 Jan;8(1):25-38. (PMID: 27757847)
Diabetes. 2016 Oct;65(10):2862-75. (PMID: 27358494)
Front Physiol. 2016 Jan 12;6:422. (PMID: 26793123)
J Physiol. 2014 Oct 15;592(20):4575-89. (PMID: 25128574)
Mol Cell Biochem. 2011 Apr;350(1-2):1-11. (PMID: 21165677)
Biochim Biophys Acta. 2015 Mar;1852(3):490-506. (PMID: 25496993)
J Biochem. 2016 Apr;159(4):379-85. (PMID: 26839319)
Sports Med. 2017 Aug;47(8):1661-1671. (PMID: 28054322)
J Appl Physiol (1985). 2010 Nov;109(5):1404-15. (PMID: 20798274)
Exp Gerontol. 2014 Oct;58:269-78. (PMID: 25193555)
Physiol Genomics. 2008 Jul 15;34(2):149-61. (PMID: 18445701)
Muscle Nerve. 2019 Dec;60(6):769-778. (PMID: 31495926)
Acta Physiol (Oxf). 2016 Nov;218(3):188-197. (PMID: 27083499)
Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2802-11. (PMID: 25596427)
Skelet Muscle. 2015 Mar 18;5:9. (PMID: 25834726)
FASEB J. 2004 Feb;18(2):227-37. (PMID: 14769817)
PLoS One. 2009 Aug 05;4(8):e6518. (PMID: 19654872)
IUBMB Life. 2012 Nov;64(11):901-10. (PMID: 23024034)
Curr Opin Cell Biol. 2015 Apr;33:95-101. (PMID: 25697963)
Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E615-26. (PMID: 24425759)
Exp Gerontol. 2014 Aug;56:182-8. (PMID: 24486129)
Physiol Genomics. 2007 Nov 14;31(3):510-20. (PMID: 17804603)
Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1421-8. (PMID: 16814248)
Int J Mol Sci. 2012 Dec 11;13(12):16971-85. (PMID: 23443131)
Autophagy. 2014 Apr;10(4):631-41. (PMID: 24451648)
J Appl Physiol (1985). 2017 Nov 1;123(5):1092-1100. (PMID: 28705993)
J Mol Cell Cardiol. 2016 Jun;95:50-6. (PMID: 27021519)
Nature. 2015 Aug 20;524(7565):309-314. (PMID: 26266977)
J Biol Chem. 2016 Oct 7;291(41):21616-21629. (PMID: 27528605)
Curr Opin Clin Nutr Metab Care. 2016 Nov;19(6):427-433. (PMID: 27537277)
Contributed Indexing:: Keywords: inactivity; mitochondria; mitochondrial biogenesis; mitophagy; muscle unloading; skeletal muscle
Entry Date(s):: Date Created: 20190910 Date Completed: 20200113 Latest Revision: 20210110
Update Code:: 20240105
PubMed Central ID:: PMC6900132
DOI:: 10.1002/mus.26702
PMID:: 31495926
: Czasopismo naukowe

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Introduction: Physical inactivity significantly contributes to loss of muscle mass and performance in bed-bound patients. Loss of skeletal muscle mitochondrial content has been well-established in muscle unloading models, but the underlying molecular mechanism remains unclear. We hypothesized that apparent unloading-induced loss of muscle mitochondrial content is preceded by increased mitophagy- and decreased mitochondrial biogenesis-signaling during the early stages of unloading.
Methods: We analyzed a comprehensive set of molecular markers involved in mitochondrial-autophagy, -biogenesis, -dynamics, and -content, in the gastrocnemius muscle of C57BL/6J mice subjected to 0- and 3-days hind limb suspension, and in biopsies from human vastus lateralis muscle obtained before and after 7 days of one-leg immobilization.
Results: In both mice and men, short-term skeletal muscle unloading results in molecular marker patterns indicative of increased receptor-mediated mitophagy and decreased mitochondrial biogenesis regulation, before apparent loss of mitochondrial content.
Discussion: These results emphasize the early-onset of skeletal muscle disuse-induced mitochondrial remodeling.
(© 2019 The Authors. Muscle & Nerve published by Wiley Periodicals, Inc.)

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