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Tytuł pozycji:

Comparative evaluation of antimicrobial activity of different types of ionic liquids.

Tytuł :
Comparative evaluation of antimicrobial activity of different types of ionic liquids.
Autorzy :
Florio W; Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Pisa, Italy.
Becherini S; Dipartimento di Farmacia, Università di Pisa, Pisa, Italy.
D'Andrea F; Dipartimento di Farmacia, Università di Pisa, Pisa, Italy. Electronic address: .
Lupetti A; Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Pisa, Italy. Electronic address: .
Chiappe C; Dipartimento di Farmacia, Università di Pisa, Pisa, Italy.
Guazzelli L; Dipartimento di Farmacia, Università di Pisa, Pisa, Italy.
Pokaż więcej
Źródło :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2019 Nov; Vol. 104, pp. 109907. Date of Electronic Publication: 2019 Jun 22.
Typ publikacji :
Comparative Study; Journal Article
Język :
English
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101484109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0191 (Electronic) Linking ISSN: 09284931 NLM ISO Abbreviation: Mater Sci Eng C Mater Biol Appl Subsets: MEDLINE
Imprint Name(s) :
Original Publication: Amsterdam : Elsevier
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Ionic Liquids/*pharmacology
Animals ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Bacteria/drug effects ; Biofilms/drug effects ; Cattle ; Hemolysis/drug effects ; Humans ; Ionic Liquids/chemical synthesis ; Ionic Liquids/chemistry ; Kinetics ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Serum Albumin, Bovine/metabolism
Contributed Indexing :
Keywords: Antimicrobial activity; Bactericidal activity; Biofilm; Hemolysis; Ionic liquids
Substance Nomenclature :
0 (Anti-Bacterial Agents)
0 (Ionic Liquids)
27432CM55Q (Serum Albumin, Bovine)
Entry Date(s) :
Date Created: 20190911 Date Completed: 20200205 Latest Revision: 20200205
Update Code :
20200716
DOI :
10.1016/j.msec.2019.109907
PMID :
31499958
Czasopismo naukowe
In order to identify most suitable ionic liquids (ILs) for potential applications in infection prevention and control, in the present study we comparatively evaluated the antimicrobial potency and hemolytic activity of 15 ILs, including 11 previously described and four newly synthesized ILs, using standard microbiological procedures against Gram-positive and Gram-negative bacteria. ILs showing the lowest minimum inhibitory concentration (MIC) were tested for their hemolytic activity. Three ILs characterized by low MIC values and low hemolytic activity, namely 1-methyl-3-dodecylimidazolium bromide, 1-dodecyl-1-methylpyrrolidinium bromide, and 1-dodecyl-1-methylpiperidinium bromide were further investigated to determine their minimum bactericidal concentration (MBC), and their ability to inhibit biofilm formation by Staphylococcus aureus or Pseudomonas aeruginosa. Killing kinetics results revealed that both Gram-positive and Gram-negative bacteria are rapidly killed after exposure to MBC of the selected ILs. Furthermore, the selected ILs efficiently inhibited biofilm formation by S. aureus or P. aeruginosa. To our knowledge, this is the first systematic study investigating the antimicrobial potential of different types of ionic liquids using standard microbiological procedures. In the overall, the selected ILs showed low hemolytic and powerful antimicrobial activity, and efficient inhibition of biofilm formation, especially against S. aureus, suggesting their possible application as anti-biofilm agents.
(Copyright © 2019 Elsevier B.V. All rights reserved.)

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