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Tytuł pozycji:

Neuromedin B mediates IL-6 and COX-2 expression through NF-κB/P65 and AP-1/C-JUN activation in human primary myometrial cells.

Tytuł:
Neuromedin B mediates IL-6 and COX-2 expression through NF-κB/P65 and AP-1/C-JUN activation in human primary myometrial cells.
Autorzy:
Zhu T; Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Chen J; Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Zhao Y; Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Zhang J; Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Peng Q; Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Huang J; Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Luo J; Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Zhang W; Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.; Hunan Engineering Research Center of Early Life Development and Disease Prevention, Hunan, China.
Źródło:
Bioscience reports [Biosci Rep] 2019 Oct 30; Vol. 39 (10).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: London : Portland Press on behalf of the Biochemical Society
Original Publication: London : The Biochemical Society, c1981-
MeSH Terms:
Cyclooxygenase 2/*biosynthesis
Gene Expression Regulation/*drug effects
Interleukin-6/*biosynthesis
Myometrium/*metabolism
Neurokinin B/*analogs & derivatives
Proto-Oncogene Proteins c-jun/*metabolism
Transcription Factor AP-1/*metabolism
Transcription Factor RelA/*metabolism
Adult ; Cells, Cultured ; Female ; Humans ; Neurokinin B/pharmacology ; Pregnancy ; Proto-Oncogene Mas
References:
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Contributed Indexing:
Keywords: AP-1/c-Jun; COX-2; IL-6; NF-κB/p65; human primary myometrial cells; neuromedin B
Substance Nomenclature:
0 (IL6 protein, human)
0 (Interleukin-6)
0 (MAS1 protein, human)
0 (Proto-Oncogene Mas)
0 (Proto-Oncogene Proteins c-jun)
0 (RELA protein, human)
0 (Transcription Factor AP-1)
0 (Transcription Factor RelA)
86933-75-7 (Neurokinin B)
87096-84-2 (neuromedin B)
EC 1.14.99.1 (Cyclooxygenase 2)
EC 1.14.99.1 (PTGS2 protein, human)
Entry Date(s):
Date Created: 20190919 Date Completed: 20200915 Latest Revision: 20211204
Update Code:
20240105
PubMed Central ID:
PMC6822491
DOI:
10.1042/BSR20192139
PMID:
31527064
Czasopismo naukowe
Neuromedin B (NMB) and its receptor regulate labor onset by mediating inflammatory factors; however the underlying mechanisms remain poorly understood. The present study is aimed to investigate the mechanisms of NMB-induced cyclo-oxygenase 2 (COX-2) expression and interleukin (IL)-6 generation in human primary myometrial cells. The results indicated that NMB could increase phosphorylation of nuclear factor κB (NF-κB) transcription factor p65 (p65) and Jun proto-oncogene, activator protein 1 (AP-1) transcription factor subunit (c-Jun), and in turn, markedly up-regulated the expression levels of COX-2 and IL-6. This up-regulation was significantly attenuated by knockdown of p65 or c-Jun, and enhanced by overexpression of p65 or c-Jun. Furthermore, we identified a potential interaction between p65 and c-Jun following NMB stimulation. In addition, a significant positive correlation was observed between the amount of phosphorylated p65 and the levels of COX-2 and IL-6, and between the amount of phosphorylated c-Jun and COX-2 and IL-6 levels. These data suggested that NMB-induced COX-2 and IL-6 expression were mediated via p65 and c-Jun activation.
(© 2019 The Author(s).)

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