Microglia: Same same, but different.

Tytuł:: Microglia: Same same, but different.
Autorzy:: Kierdorf K; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany .; Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Prinz M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany .; Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
Źródło:: The Journal of experimental medicine [J Exp Med] 2019 Oct 07; Vol. 216 (10), pp. 2223-2225. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji:: Journal Article; Comment
Język:: English
Imprint Name(s):: Original Publication: New York, NY : Rockefeller University Press
MeSH Terms:: Macrophage Colony-Stimulating Factor*
Microglia*
Animals ; Interpersonal Relations ; Mice ; Receptor, Macrophage Colony-Stimulating Factor ; Signal Transduction
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Substance Nomenclature:: 81627-83-0 (Macrophage Colony-Stimulating Factor)
EC 2.7.10.1 (Receptor, Macrophage Colony-Stimulating Factor)
Entry Date(s):: Date Created: 20190919 Date Completed: 20200529 Latest Revision: 20231014
Update Code:: 20240105
PubMed Central ID:: PMC6781008
DOI:: 10.1084/jem.20191535
PMID:: 31527071
: Czasopismo naukowe

Microglial identity in the central nervous system (CNS) is dependent on colony stimulating factor 1 receptor (CSF-1R) signaling and its ligands IL-34 and colony stimulating factor 1 (CSF-1). In this issue of JEM , Kana et al. (https://doi.org/10.1084/jem.20182037) make the important discovery that CSF-1, but not IL-34, orchestrates cerebellar microglial homeostasis in mice, and its deficiency resulted in severe cerebellar dysfunctions accompanied by defects in motor function and social behavior.
(© 2019 Prinz and Kierdorf.)

Comment on: J Exp Med. 2019 Oct 7;216(10):2265-2281. (PMID: 31350310)

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