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Tytuł pozycji:

Genetic polymorphism in ERCC5 and breast cancer risk.

Tytuł :
Genetic polymorphism in ERCC5 and breast cancer risk.
Autorzy :
Shakil Malik S; Microbiology and Biotechnology Research Lab, Fatima Jinnah Women University, The Mall Rawalpindi.
Mubarik S; Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China.
Baig M; Surgical Unit, Fauji Foundation Hospital, Rawalpindi.
Masood N; Microbiology and Biotechnology Research Lab, Fatima Jinnah Women University, The Mall Rawalpindi.
Chaudhry N; Armed Forces Institute of Pathology, Rawalpindi.
Pokaż więcej
Źródło :
Molecular biology research communications [Mol Biol Res Commun] 2019 Mar; Vol. 8 (1), pp. 27-31.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Shiraz : Shiraz University, 2012-
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Contributed Indexing :
Keywords: ARMS-PCR; ERCC5; NER; breast cancer
Entry Date(s) :
Date Created: 20190919 Latest Revision: 20200930
Update Code :
20210914
PubMed Central ID :
PMC6510213
DOI :
10.22099/mbrc.2019.32294.1383
PMID :
31528641
Czasopismo naukowe
ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers. Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 females including one hundred breast cancer cases and age matched seventy-five healthy controls. Genotyping was performed with Tetra amplification-refractory mutation system (ARMS) PCR and products were observed through electrophoresis. Multivariate logistic regression was used to calculate odds ratio (OR) and 95% confidence interval (95% CI) investigating relationship between genotypes, clinical parameters and risk of breast cancer. Statistical analysis exhibited significant relationship between the TC genotype (OR=7.2, 95% CI=1.5-34.3) and increased breast cancer risk. Moreover, family history (OR=6.25; 95% CI= 2.61-15.00) and late menopause (OR=2.41; 95% CI=1.20-4.83) were found to be breast cancer associated risk factors. In conclusion, ERCC5 (rs1047768 T>C) polymorphism may contribute towards increased risk of breast cancer in Pakistani population.

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