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Tytuł pozycji:

Association between circulating zinc/ferritin levels and parent Conner's scores in children with attention deficit hyperactivity disorder.

Tytuł :
Association between circulating zinc/ferritin levels and parent Conner's scores in children with attention deficit hyperactivity disorder.
Autorzy :
El-Baz FM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, P.O. Box 11381, Egypt.
Youssef AM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, P.O. Box 11381, Egypt.
Khairy E; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, P.O. Box 11381, Egypt. Electronic address: .
Ramadan D; General Practitioner at Ministry of Health, Egypt.
Youssef WY; Pediatrics Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, P.O. Box 11381, Egypt.
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Źródło :
European psychiatry : the journal of the Association of European Psychiatrists [Eur Psychiatry] 2019 Oct; Vol. 62, pp. 68-73. Date of Electronic Publication: 2019 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: 2020- : Cambridge : Cambridge University Press
Original Publication: Paris : Editions scientifiques Elsevier, c1991-
MeSH Terms :
Attention Deficit Disorder with Hyperactivity/*blood
Ferritins/*blood
Zinc/*blood
Adolescent ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Child ; Female ; Humans ; Intelligence ; Male ; Prospective Studies ; Psychomotor Agitation/blood ; Psychomotor Agitation/psychology
Contributed Indexing :
Keywords: Attention-deficit*; ELISA*; Ferritin*; Hyperactivity disorder*; Zinc*
Substance Nomenclature :
9007-73-2 (Ferritins)
J41CSQ7QDS (Zinc)
Entry Date(s) :
Date Created: 20190924 Date Completed: 20200731 Latest Revision: 20200731
Update Code :
20210210
DOI :
10.1016/j.eurpsy.2019.09.002
PMID :
31546229
Czasopismo naukowe
ADHD is one of the most common neurobehavioral disorders among children and adolescents. In this prospective study, we aimed to measure circulating zinc and ferritin levels in children with ADHD, pick up the deficient ones to give zinc and iron supplements then compare before and after treatment according to their Conner's scores and Wecsler IQ test. Current study included fifty children diagnosed as having ADHD by DSMV criteria, their zinc and ferritin levels were measured by Colorimetric method and enzyme-linked immunosorbent assay (ELISA) respectively. They were divided into: group I (zinc only deficient),group II (zinc and ferritin deficient),group III (non-deficient), cases with mineral deficiency received zinc (55 mg/day) and/or iron (6 mg/kg/day) for 6 months then reassessed by parent Conner's rating scale. In group 1, there was no significant difference between the Wecsler verbal and non-verbal IQ scores and oppositional and cognitive problems in Conner's scores before and after zinc supplements, although there was significant improvement in attention, hyperactivity, emotional liability and impulsivity. In group II, there was significant improvement in verbal and total IQ but not in performance IQ, also there was significant improvement in hyperactivity, emotional liability and impulsivity with no significant difference in oppositional, cognitive problems and inattention before and after zinc/ iron supplements. In Conclusion, Zinc supplements in adjuvant to the main treatment significantly improved symptoms of ADHD children. However, a combined zinc and iron supplements was superior to zinc alone in alleviating ADHD symptoms as well as IQ improvement.
(Copyright © 2019 Elsevier Masson SAS. All rights reserved.)

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