Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies.

Tytuł:: Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies.
Autorzy:: Bharathi Devi SR; RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, India.
Coral K; RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, India.
Gayathree K; RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, India.
Bharathselvi M; RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, India.
Sivasankar S; RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, India.
Biswas J; Department of Uveitis, Medical Research Foundation, Chennai, India.
Rishi P; Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Chennai, India.
Natarajan S; Aditya Jyot Eye Hospital, Mumbai, India.
Badrinath SS; Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Chennai, India.
Angayarkanni N; RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, India.
Źródło:: Indian journal of ophthalmology [Indian J Ophthalmol] 2019 Oct; Vol. 67 (10), pp. 1762-1765.
Typ publikacji:: Case Reports
Język:: English
Imprint Name(s):: Publication: Mumbai : Medknow Publications
Original Publication: Bombay : All-India Ophthalmological Society
MeSH Terms:: Gene Expression Regulation*
Tissue Donors*
Adiponectin/*biosynthesis
Aryldialkylphosphatase/*biosynthesis
Diabetes Mellitus, Type 2/*diagnosis
Eye Proteins/*biosynthesis
Nerve Growth Factors/*biosynthesis
Retina/*pathology
Serpins/*biosynthesis
Adiponectin/genetics ; Aged, 80 and over ; Aryldialkylphosphatase/genetics ; Biomarkers/metabolism ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Eye Proteins/genetics ; Female ; Humans ; Male ; Middle Aged ; Nerve Growth Factors/genetics ; Oxidative Stress ; RNA/genetics ; Retina/metabolism ; Retinal Diseases ; Serpins/genetics
References:: Lancet. 2011 Jul 2;378(9785):31-40. (PMID: 21705069)
Clin Chim Acta. 2006 May;367(1-2):103-7. (PMID: 16426593)
JCI Insight. 2017 Jul 20;2(14):null. (PMID: 28724805)
Mol Vis. 2012;18:830-7. (PMID: 22511846)
Exp Eye Res. 2018 Aug;173:179-187. (PMID: 29752946)
Cell Metab. 2013 Jan 8;17(1):20-33. (PMID: 23312281)
Am J Ophthalmol. 1994 Oct 15;118(4):445-50. (PMID: 7943121)
Diabetes Care. 2007 Aug;30(8):1995-7. (PMID: 17507696)
Contributed Indexing:: Keywords: Adiponectin and paraoxonase; PEDF; VEGF; diabetic retinopathy
Substance Nomenclature:: 0 (Adiponectin)
0 (Biomarkers)
0 (Eye Proteins)
0 (Nerve Growth Factors)
0 (Serpins)
0 (pigment epithelium-derived factor)
63231-63-0 (RNA)
EC 3.1.8.1 (Aryldialkylphosphatase)
Entry Date(s):: Date Created: 20190925 Date Completed: 20200518 Latest Revision: 20200518
Update Code:: 20240105
PubMed Central ID:: PMC6786156
DOI:: 10.4103/ijo.IJO_400_19
PMID:: 31546558
: Raport

Pełny tekst

We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.
Competing Interests: There are no conflicts of interest.

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