-
Tytuł:
-
A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya.
-
Autorzy:
-
Magai DN; Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Wellcome Trust Research Programme, PO Box 230-8010, Kilifi, Kenya. .; Department of Clinical Neuro- and Developmental Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. .
Mwaniki M; Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Wellcome Trust Research Programme, PO Box 230-8010, Kilifi, Kenya.; Afya Research Africa, Nairobi, 00202, Kenya.
Abubakar A; Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Wellcome Trust Research Programme, PO Box 230-8010, Kilifi, Kenya.; Department of Public Health, Pwani University, P.O. Box 195-80108, Kilifi, Kenya.; Institute for Human Development, Aga Khan University, P.O. Box 30270-00100, Nairobi, Kenya.; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
Mohammed S; Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Wellcome Trust Research Programme, PO Box 230-8010, Kilifi, Kenya.
Gordon AL; Faculty of Life Sciences and Medicine, King's College London, Strand, London, WC2R2LS, England, UK.
Kalu R; Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Wellcome Trust Research Programme, PO Box 230-8010, Kilifi, Kenya.
Mwangi P; Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Wellcome Trust Research Programme, PO Box 230-8010, Kilifi, Kenya.
Koot HM; Department of Clinical Neuro- and Developmental Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
Newton CR; Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Wellcome Trust Research Programme, PO Box 230-8010, Kilifi, Kenya.; Department of Public Health, Pwani University, P.O. Box 195-80108, Kilifi, Kenya.; Institute for Human Development, Aga Khan University, P.O. Box 30270-00100, Nairobi, Kenya.; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
-
Źródło:
-
BMC research notes [BMC Res Notes] 2019 Sep 23; Vol. 12 (1), pp. 617. Date of Electronic Publication: 2019 Sep 23.
-
Typ publikacji:
-
Journal Article; Randomized Controlled Trial
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: London : Biomed Central, 2008.
-
MeSH Terms:
-
Albumins/*therapeutic use
Hyperbilirubinemia, Neonatal/*therapy
Phototherapy/*methods
Saline Solution/*administration & dosage
Bilirubin/blood ; Blood Component Transfusion/methods ; Female ; Hospitalization ; Humans ; Hyperbilirubinemia, Neonatal/mortality ; Hyperbilirubinemia, Neonatal/physiopathology ; Infant ; Infant Mortality ; Infant, Newborn ; Kenya ; Male
-
References:
-
Eur J Pediatr. 1999 Feb;158(2):111-4. (PMID: 10048606)
Arch Dis Child. 1975 Nov;50(11):833-6. (PMID: 1108807)
Pediatr Int. 2001 Feb;43(1):8-11. (PMID: 11207991)
Pediatr Int. 2002 Oct;44(5):488-92. (PMID: 12225546)
Arch Dis Child. 2003 May;88(5):438-43. (PMID: 12716721)
Pediatrics. 1962 Oct;30:613-21. (PMID: 13939465)
Trop Med Int Health. 2005 Nov;10(11):1114-20. (PMID: 16262736)
Niger J Med. 2007 Oct-Dec;16(4):354-9. (PMID: 18080595)
Ann Trop Paediatr. 2008 Sep;28(3):217-26. (PMID: 18727851)
Trop Med Int Health. 2009 Mar;14(3):301-10. (PMID: 19187520)
Acta Paediatr. 2010 Feb;99(2):291-7. (PMID: 20353499)
West Afr J Med. 1990 Oct-Dec;9(4):252-7. (PMID: 2083201)
Cochrane Database Syst Rev. 2011 Dec 07;(12):CD007969. (PMID: 22161417)
Evid Based Child Health. 2013 Jan;8(1):204-49. (PMID: 23878128)
N Engl J Med. 2013 Nov 21;369(21):2021-30. (PMID: 24256380)
J Trop Pediatr. 2014 Jun;60(3):264-6. (PMID: 24415750)
Cochrane Database Syst Rev. 2014 Jun 10;(6):CD010212. (PMID: 24913724)
Eur J Pediatr. 2015 Feb;174(2):177-81. (PMID: 25005717)
Iran J Public Health. 2016 May;45(5):558-68. (PMID: 27398328)
Cochrane Database Syst Rev. 2017 Aug 01;8:CD011891. (PMID: 28762235)
BMJ Paediatr Open. 2017 Nov 25;1(1):e000105. (PMID: 29637134)
Arch Dis Child. 1972 Apr;47(252):250-6. (PMID: 5023474)
Arch Dis Child. 1968 Apr;43(228):151-4. (PMID: 5645688)
Pediatrics. 1994 Oct;94(4 Pt 1):558-65. (PMID: 7755691)
Arch Fr Pediatr. 1993 May;50(5):399-402. (PMID: 8239891)
Eur J Pediatr. 1997 Oct;156(10):803-7. (PMID: 9365074)
-
Grant Information:
-
077092/B/05/Z United Kingdom WT_ Wellcome Trust
-
Contributed Indexing:
-
Keywords: Albumin; Neonatal jaundice; Neonates; Saline; Sub-Saharan Africa
-
Molecular Sequence:
-
ISRCTN ISRCTN89732754
-
Substance Nomenclature:
-
0 (Albumins)
0 (Saline Solution)
RFM9X3LJ49 (Bilirubin)
-
Entry Date(s):
-
Date Created: 20190925 Date Completed: 20200204 Latest Revision: 20200225
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC6757356
-
DOI:
-
10.1186/s13104-019-4632-2
-
PMID:
-
31547861
-
Objective: The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outcomes were the need for exchange transfusion, inpatient mortality, neurological outcomes at discharge, and development outcomes at 12-months follow-up.
Results: One hundred and eighteen neonates were randomly assigned to phototherapy and 20% albumin (n = 59) and phototherapy and saline (n = 69). The median age at admission was 5 (interquartile range (IQR) 3-6) days, and the median gestation was 36 (IQR 36-38) weeks. No significant differences were found in the change in TSB (Mann-Whitney U =609, p = 0.98) and rate of change in TSB per hour after treatment (Mann-Whitney U = 540, p = 0.39) between the two groups. There were no significant differences between the two groups in the proportion of participants who required exchange transfusion (χ 2 (2) = 0.36, p = 0.546); repeat phototherapy (χ 2 (2) = 2.37, p = 0.123); and those who died (χ 2 (2) = 0.92, p = 0.337). Trial registration The trial was registered in the International Standardized Randomized Controlled Trial Number (ISRCTN); trial registration number ISRCTN89732754.
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.
