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Tytuł pozycji:

Bistable switches as integrators and actuators during cell cycle progression.

Tytuł:
Bistable switches as integrators and actuators during cell cycle progression.
Autorzy:
Stallaert W; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Kedziora KM; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Chao HX; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Purvis JE; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Źródło:
FEBS letters [FEBS Lett] 2019 Oct; Vol. 593 (20), pp. 2805-2816. Date of Electronic Publication: 2019 Oct 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
Język:
English
Imprint Name(s):
Publication: Jan. 2016- : West Sussex : John Wiley & Sons Ltd.
Original Publication: Amsterdam, North-Holland on behalf of the Federation of European Biochemical Societies.
MeSH Terms:
DNA Repair*/drug effects
Cell Cycle/*genetics
Cell Cycle Checkpoints/*genetics
Cyclin-Dependent Kinases/*genetics
E2F Transcription Factors/*genetics
Retinoblastoma Protein/*genetics
Animals ; Cell Cycle/drug effects ; Cell Cycle Checkpoints/drug effects ; Cyclin-Dependent Kinases/metabolism ; DNA Damage/drug effects ; DNA Replication/drug effects ; E2F Transcription Factors/metabolism ; Eukaryotic Cells/cytology ; Eukaryotic Cells/drug effects ; Eukaryotic Cells/metabolism ; Gene Expression Regulation ; Humans ; Intercellular Signaling Peptides and Proteins/pharmacology ; Mitogens/pharmacology ; Retinoblastoma Protein/metabolism ; Signal Transduction
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Grant Information:
DP2 HD091800 United States HD NICHD NIH HHS; F30 CA213876 United States CA NCI NIH HHS; R01 GM138834 United States GM NIGMS NIH HHS; 1845796 International Division of Molecular and Cellular Biosciences
Contributed Indexing:
Keywords: DNA damage; bistability; cell cycle; cell signaling
Substance Nomenclature:
0 (E2F Transcription Factors)
0 (Intercellular Signaling Peptides and Proteins)
0 (Mitogens)
0 (Retinoblastoma Protein)
EC 2.7.11.22 (Cyclin-Dependent Kinases)
Entry Date(s):
Date Created: 20191001 Date Completed: 20200617 Latest Revision: 20210610
Update Code:
20240105
PubMed Central ID:
PMC7881439
DOI:
10.1002/1873-3468.13628
PMID:
31566708
Czasopismo naukowe
Progression through the cell cycle is driven by bistable switches-specialized molecular circuits that govern transitions from one cellular state to another. Although the mechanics of bistable switches are relatively well understood, it is less clear how cells integrate multiple sources of molecular information to engage these switches. Here, we describe how bistable switches act as hubs of information processing and examine how variability, competition, and inheritance of molecular signals determine the timing of the Rb-E2F bistable switch that controls cell cycle entry. Bistable switches confer both robustness and plasticity to cell cycle progression, ensuring that cell cycle events are performed completely and in the correct order, while still allowing flexibility to cope with ongoing stress and changing environmental conditions.
(© 2019 Federation of European Biochemical Societies.)

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