Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non-inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid. - OpacWWW

Tytuł:: Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non-inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid.
Autorzy:: Kim SH; Department of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim ER; Department of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim K; Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea.
Kim TJ; Department of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Hong SN; Department of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Chang DK; Department of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim YH; Department of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Źródło:: Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society [Dig Endosc] 2020 May; Vol. 32 (4), pp. 600-607. Date of Electronic Publication: 2019 Nov 11.
Typ publikacji:: Comparative Study; Journal Article; Randomized Controlled Trial
Język:: English
Imprint Name(s):: Publication: 2019- : Richmond, Vic., Australia : John Wiley & Sons Australia, Ltd.
Original Publication: Tokyo, Japan : The Society, c1989-
MeSH Terms:: Colonoscopy*
Ascorbic Acid/*administration & dosage
Bisacodyl/*administration & dosage
Cathartics/*administration & dosage
Polyethylene Glycols/*administration & dosage
Surface-Active Agents/*administration & dosage
Adult ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Patient Compliance ; Prospective Studies ; Suppositories ; Surveys and Questionnaires
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Levin B, Lieberman DA, McFarland B et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: A joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 2008; 134: 1570-95.
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Contributed Indexing:: Keywords: Boston Bowel Preparation Scale; bisacodyl; colonoscopy; compliance; polyethylene glycol
Substance Nomenclature:: 0 (Cathartics)
0 (Suppositories)
0 (Surface-Active Agents)
10X0709Y6I (Bisacodyl)
3WJQ0SDW1A (Polyethylene Glycols)
PQ6CK8PD0R (Ascorbic Acid)
Entry Date(s):: Date Created: 20191002 Date Completed: 20210322 Latest Revision: 20210322
Update Code:: 20240104
DOI:: 10.1111/den.13548
PMID:: 31574170
: Czasopismo naukowe

Pełny tekst

Background and Aim: Appropriate bowel cleansing before colonoscopy is an important factor in increasing the detection rate of lesions. Low-volume polyethylene glycol (PEG) plus ascorbic acid (PEG-Asc) reduces the dosage of bowel preparation agent, but still presents discomfort to patients. The primary aim of the present study was to compare the efficacy of bowel cleansing between 2 L PEG-Asc (control) and 1 L PEG-Asc with bisacodyl suppository (suppository) groups, and the secondary aim was to investigate complications and tolerability between the two groups.
Methods: This was a single-center prospective randomized controlled study. We identified 168 patients scheduled for colonoscopy between August 2017 and January 2018 and randomly assigned them to the control or to the suppository groups. Efficacy of bowel cleansing was assessed using the Boston Bowel Preparation Scale (BBPS), and side-effects were surveyed using questionnaires.
Results: No significant difference was detected in baseline characteristics including insertion and withdrawal times, and adenoma detection rates between the two groups. Total BBPS score was 7.93 ± 1.06 and 7.74 ± 1.02 in the control and suppository groups, respectively (P = 0.22). Incidence of abdominal pain and nausea was not statistically different, whereas that of sleep disturbance and anal discomfort was higher in the control group. (P = 0.00).
Conclusions: One liter PEG-Asc with bisacodyl suppository resulted in an equivalent bowel-cleansing outcome with reduced patient discomfort compared to 2 L PEG-Asc. Therefore, PEG-Asc with bisacodyl suppository represents a potential alternative and increases patient compliance with bowel preparation.
(© 2019 Japan Gastroenterological Endoscopy Society.)

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Informacja

Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non-inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid.