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Tytuł:
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Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates.
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Autorzy:
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Chuma IS; Work Group Neglected Tropical Diseases, Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.; Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.; Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania.
Roos C; Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.; Gene Bank of Primates, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.
Atickem A; Department of Zoological Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Bohm T; African Parks, Odzala-Kokoua National Park, Brazzaville, Republic of the Congo.
Anthony Collins D; Jane Goodall Institute, Kigoma, Tanzania.
Grillová L; Biology of Spirochetes Unit, Department of Microbiology, Institut Pasteur, Paris, France.; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Hallmaier-Wacker LK; Work Group Neglected Tropical Diseases, Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.; Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.
Kazwala RR; Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania.
Keyyu JD; Tanzania Wildlife Research Institute, Arusha, Tanzania.
Lüert S; Work Group Neglected Tropical Diseases, Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.; Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.
Maloueki U; African Parks, Odzala-Kokoua National Park, Brazzaville, Republic of the Congo.; Department of Biology, Faculty of Sciences, Kinshasa University, Kinshasa, Democratic Republic of the Congo.
Oppelt J; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Petrželková KJ; Institute of Vertebrate Biology, Czech Academy of Sciences, Brno, Czech Republic.; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic.; Zoo Liberec, Liberec, Czech Republic.
Piel A; School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, UK.; Greater Mahale Ecosystem Research and Conservation Project, Dar es Salaam, Tanzania.
Stewart FA; School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, UK.; Greater Mahale Ecosystem Research and Conservation Project, Dar es Salaam, Tanzania.
Šmajs D; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Knauf S; Work Group Neglected Tropical Diseases, Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany. .; Division of Microbiology and Animal Hygiene, University of Goettingen, Goettingen, Germany. .
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Źródło:
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Scientific reports [Sci Rep] 2019 Oct 02; Vol. 9 (1), pp. 14243. Date of Electronic Publication: 2019 Oct 02.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: London : Nature Publishing Group, copyright 2011-
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MeSH Terms:
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Host Specificity*
Cercopithecus/*microbiology
Chlorocebus aethiops/*microbiology
Monkey Diseases/*transmission
Papio anubis/*microbiology
Papio cynocephalus/*microbiology
Treponema/*classification
Treponemal Infections/*veterinary
Animals ; Ape Diseases/epidemiology ; Ape Diseases/microbiology ; Ape Diseases/transmission ; Congo/epidemiology ; Feces/microbiology ; Genetic Association Studies ; Genetic Variation ; Gorilla gorilla/microbiology ; Monkey Diseases/epidemiology ; Monkey Diseases/microbiology ; Multilocus Sequence Typing ; Phylogeny ; Polymorphism, Single Nucleotide ; Species Specificity ; Tanzania/epidemiology ; Treponema/genetics ; Treponema/isolation & purification ; Treponemal Infections/epidemiology ; Treponemal Infections/microbiology ; Treponemal Infections/transmission
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References:
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SCR Organism:
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Cercopithecus mitis; Treponema pallidum subsp. pertenue
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Entry Date(s):
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Date Created: 20191004 Date Completed: 20201109 Latest Revision: 20210110
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Update Code:
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20240104
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PubMed Central ID:
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PMC6775232
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DOI:
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10.1038/s41598-019-50779-9
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PMID:
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31578447
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In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
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