Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Potential role of IL-37 signaling pathway in feedback regulation of autoimmune Hashimoto thyroiditis.

Tytuł :
Potential role of IL-37 signaling pathway in feedback regulation of autoimmune Hashimoto thyroiditis.
Autorzy :
Ren CP; Department of Microbiology and Parasitology, Anhui Provincial Laboratory of Pathogen Biology, Anhui Provincial Laboratory of Zoonoses, Laboratory of Tropical and Parasitic Diseases Control, School of Basic Medical Sciences, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
Sun L; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 210 JiXi Road, Hefei, 230032, Anhui, People's Republic of China.
Liu FC; Department of Microbiology and Parasitology, Anhui Provincial Laboratory of Pathogen Biology, Anhui Provincial Laboratory of Zoonoses, Laboratory of Tropical and Parasitic Diseases Control, School of Basic Medical Sciences, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
Zuo CL; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 210 JiXi Road, Hefei, 230032, Anhui, People's Republic of China.
Liu M; Department of Microbiology and Parasitology, Anhui Provincial Laboratory of Pathogen Biology, Anhui Provincial Laboratory of Zoonoses, Laboratory of Tropical and Parasitic Diseases Control, School of Basic Medical Sciences, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
Gao W; Antagen Institute for Biomedical Research, Boston, MA, 02118, USA. .
Shen JJ; Department of Microbiology and Parasitology, Anhui Provincial Laboratory of Pathogen Biology, Anhui Provincial Laboratory of Zoonoses, Laboratory of Tropical and Parasitic Diseases Control, School of Basic Medical Sciences, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China. .
Pokaż więcej
Źródło :
Histochemistry and cell biology [Histochem Cell Biol] 2019 Dec; Vol. 152 (6), pp. 467-473. Date of Electronic Publication: 2019 Oct 04.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Berlin : Springer,
MeSH Terms :
Signal Transduction*/genetics
Hashimoto Disease/*metabolism
Interleukin-1/*metabolism
Adult ; Animals ; Cells, Cultured ; Feedback, Physiological ; Female ; Humans ; Interleukin-1/analysis ; Interleukin-1/genetics ; Middle Aged ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Young Adult
References :
Trends Endocrinol Metab. 2014 Dec;25(12):656-64. (PMID: 25306886)
Mediators Inflamm. 2013;2013:639712. (PMID: 24174711)
Cytokine. 2015 Mar;72(1):113-4. (PMID: 25592113)
J Endocrinol Invest. 2019 Feb;42(2):199-205. (PMID: 29796799)
Nat Commun. 2014 Sep 03;5:4711. (PMID: 25182023)
Front Immunol. 2012 Oct 29;3:322. (PMID: 23112799)
Autoimmun Rev. 2014 Apr-May;13(4-5):391-7. (PMID: 24434360)
Mediators Inflamm. 2014;2014:165742. (PMID: 24733959)
Nat Immunol. 2015 Apr;16(4):354-65. (PMID: 25729923)
APMIS. 2015 Dec;123(12):1025-31. (PMID: 26547368)
Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16711-6. (PMID: 21873195)
Eur J Endocrinol. 2003 Jan;148(1):1-9. (PMID: 12534350)
J Transl Med. 2014 Mar 16;12:69. (PMID: 24629023)
Autoimmun Rev. 2015 Feb;14(2):174-80. (PMID: 25461470)
Nat Immunol. 2012 Oct;13(10):925-31. (PMID: 22990890)
Nat Immunol. 2003 Sep;4(9):920-7. (PMID: 12925853)
Mol Cell Endocrinol. 2008 Mar 12;284(1-2):28-37. (PMID: 18280640)
Int J Clin Exp Med. 2015 May 15;8(5):6677-81. (PMID: 26221205)
PLoS Pathog. 2014 Nov 06;10(11):e1004462. (PMID: 25375146)
Semin Immunol. 2013 Dec 15;25(6):466-8. (PMID: 24275599)
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15178-83. (PMID: 25294929)
Clin Exp Immunol. 2011 Aug;165(2):148-54. (PMID: 21623768)
Nat Immunol. 2010 Nov;11(11):1014-22. (PMID: 20935647)
Allergy. 2015 Apr;70(4):366-73. (PMID: 25557042)
Clin Exp Immunol. 2014 Jun;176(3):438-51. (PMID: 24527881)
Grant Information :
81802027 National Natural Science Foundation of China; 81271864 National Natural Science Foundation of China; 1608085MH173 Anhui Provincial National Science Foundation
Contributed Indexing :
Keywords: Chronic lymphocytic thyroiditis; Hashimoto’s thyroiditis; IL-37; SIGIRR
Substance Nomenclature :
0 (IL37 protein, human)
0 (Interleukin-1)
0 (RNA, Messenger)
Entry Date(s) :
Date Created: 20191005 Date Completed: 20191206 Latest Revision: 20191217
Update Code :
20210210
DOI :
10.1007/s00418-019-01820-5
PMID :
31584126
Czasopismo naukowe
IL-37, the anti-inflammatory cytokine of the IL-1 family, plays several key roles in the regulation of autoimmune diseases. Yet, its role in Hashimoto's thyroiditis (HT) is not clear. In the present study, we found that, in tissues from HT patients, most of the follicular epithelial cells were positive for both IL-37 and single Ig IL-1-related receptor (SIGIRR) by immunohistochemical staining, while the infiltrating lymphocytes and other inflammatory cells hardly expressed any. Meanwhile, mRNA expression levels of IL-37 in peripheral blood mononuclear cells (PBMC) of HT patients were significantly higher than those in normal controls measured by quantitative real-time PCR. Finally, we studied the possible role of IL-37 in IFN-γ-stimulated rat FRTL-5 cells. The results showed that IL-1β, TNF-α, and MCP-1 mRNA levels were significantly decreased, while the expression of IL-4 mRNA was dramatically up-regulated in IFN-γ-stimulated rat thyroid cell line FRTL-5 pre-treated with IL-37. The current study, for the first time, demonstrated that the IL-37 network is involved in Hashimoto's thyroiditis, and IL-37 signaling pathway may ameliorate the excessive autoimmune responses in this chronic lymphocytic thyroiditis.
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies