-
Tytuł:
-
Fe 3 O 4 @.
-
Autorzy:
-
Sun Y; State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou Key Laboratory of Biomaterials and Technologies, Southeast University, Nanjing 210096, China.
Shi F; Department of Oncology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
Niu Y; China Pharmaceutical University, Nanjing 210009, China.
Zhang Y; State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou Key Laboratory of Biomaterials and Technologies, Southeast University, Nanjing 210096, China.
Xiong F; State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou Key Laboratory of Biomaterials and Technologies, Southeast University, Nanjing 210096, China. Electronic address: .
-
Źródło:
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2019 Dec 01; Vol. 184, pp. 110528. Date of Electronic Publication: 2019 Sep 24.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: Amsterdam ; New York : Elsevier, c1993-
-
MeSH Terms:
-
Antineoplastic Agents/*chemistry
Ferrosoferric Oxide/*chemistry
Nanoparticles/*chemistry
Oleic Acid/*chemistry
Poloxamer/*chemistry
Superoxide Dismutase/*chemistry
Triglycerides/*chemistry
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Disease Models, Animal ; Drug Screening Assays, Antitumor ; Ferrosoferric Oxide/pharmacology ; Hep G2 Cells ; Hepatocytes/chemistry ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Lipectomy ; Male ; Oleic Acid/pharmacology ; Particle Size ; Poloxamer/pharmacology ; Rats ; Superoxide Dismutase/metabolism ; Surface Properties ; Triglycerides/pharmacology ; Tumor Cells, Cultured
-
Contributed Indexing:
-
Keywords: Fe(3)O(4) nanoparticles; Lipid deposition; Liposuction effect; Nano-enzyme; Poloxamer
-
Substance Nomenclature:
-
0 (Antineoplastic Agents)
0 (Triglycerides)
106392-12-5 (Poloxamer)
2UMI9U37CP (Oleic Acid)
EC 1.15.1.1 (Superoxide Dismutase)
XM0M87F357 (Ferrosoferric Oxide)
-
Entry Date(s):
-
Date Created: 20191008 Date Completed: 20200423 Latest Revision: 20200423
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.colsurfb.2019.110528
-
PMID:
-
31590050
-
Lipid deposition induced various diseases including nonalcoholic fatty liver and hyperlipemia. The excessive accumulation of triglyceride (TG) and the deposition of fat were the two most critical causes. Here, we developed Fe 3 O 4 @OA@Poloxamer nanoparticles (NPs) with amphiphilic structures, which exhibited an excellent role in eliminating excess TG. Hydrophobic TG was adsorbed efficiently by Fe 3 O 4 @OA@Poloxamer NPs through the "liposuction effect" and the formation of NPs@TG complex was then conducted. The NPs@TG complex was further enclosed by the endosome based on the endocytosis and subsequently was taken into the lysosome, degrading with the help of lipases. Meanwhile, the "nano-enzyme effect" of Fe 3 O 4 NPs recovered the lipid-regulated proteins including PPARα, further triggering biodegradation pathways of TG, although the lipid-regulated proteins were obviously inhibited in the high-fat hepatocytes models. These two mechanisms of Fe 3 O 4 @OA@Poloxamer NPs together achieved the down-regulation of TG in vivo and in vitro. Therefore, our findings provided a novel thought in treating these diseases associated with lipid deposition, that is, nanoparticles modified by specific structure exhibit a superior TG removal.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
