Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response.

Szczegóły
Abstrakt

Tytuł:: Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response.
Autorzy:: Ames KC; Department of Neuroscience, Columbia University, New York, United States.; Zuckerman Institute, Columbia University, New York, United States.; Grossman Center for the Statistics of Mind, Columbia University, New York, United States.; Center for Theoretical Neuroscience, Columbia University, New York, United States.
Churchland MM; Department of Neuroscience, Columbia University, New York, United States.; Zuckerman Institute, Columbia University, New York, United States.; Grossman Center for the Statistics of Mind, Columbia University, New York, United States.; Kavli Institute for Brain Science, Columbia University, New York, United States.
Źródło:: ELife [Elife] 2019 Oct 09; Vol. 8. Date of Electronic Publication: 2019 Oct 09.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
MeSH Terms:: Functional Laterality*
Movement*
Arm/*innervation
Motor Cortex/*physiology
Motor Neurons/*physiology
Animals ; Macaca mulatta ; Male
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Grant Information:: 1U19NS104649 United States NS NINDS NIH HHS; U19 NS104649 United States NS NINDS NIH HHS; R01 NS100066 United States NS NINDS NIH HHS; P30 EY019007 United States EY NEI NIH HHS; CRCNS R01 NS100066 United States NH NIH HHS; 1DP2NS083037 United States NS NINDS NIH HHS; DP2 NS083037 United States NS NINDS NIH HHS
Contributed Indexing:: Keywords: arm movement; bimanual; motor cortex; neuroscience; rhesus macaque; state space
Entry Date(s):: Date Created: 20191010 Date Completed: 20200211 Latest Revision: 20240216
Update Code:: 20240216
PubMed Central ID:: PMC6785221
DOI:: 10.7554/eLife.46159
PMID:: 31596230
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Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either arm. Responses were strongly arm-dependent, raising two possibilities. First, population-level signals might differ depending on the arm used. Second, the same population-level signals might be present, but distributed differently across neurons. The data supported this second hypothesis. Muscle activity was accurately predicted by activity in either the ipsilateral or contralateral hemisphere. More generally, we failed to find signals unique to the contralateral hemisphere. Yet if signals are shared across hemispheres, how do they avoid impacting the wrong arm? We found that activity related to each arm occupies a distinct subspace, enabling muscle-activity decoders to naturally ignore signals related to the other arm.
Competing Interests: KA, MC No competing interests declared
(© 2019, Ames and Churchland.)

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