Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents.

Tytuł:: Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents.
Autorzy:: Šťastný M; Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Štengl V; Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Štenglová-Netíková I; 1st Faculty of Medicine, Charles University in Prague, Ovocný trh, Czech Republic.
Šrámová-Slušná M; Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Janoš P; Faculty of the Environment, J.E.Purkyně University in Ústí nad Labem, Ústí nad Labem, Czech Republic.
Źródło:: PloS one [PLoS One] 2019 Oct 11; Vol. 14 (10), pp. e0223117. Date of Electronic Publication: 2019 Oct 11 (Print Publication: 2019).
Typ publikacji:: Comparative Study; Journal Article
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Cytostatic Agents/*chemistry
Doxorubicin/*analogs & derivatives
Nanostructures/*chemistry
Titanium/*chemistry
Water Pollutants, Chemical/*chemistry
Adsorption ; Crystallization ; Cytostatic Agents/isolation & purification ; Decontamination/methods ; Doxorubicin/chemistry ; Doxorubicin/isolation & purification ; Hydrolysis ; Particle Size ; Sodium Hydroxide/chemistry ; Sodium Hypochlorite/chemistry ; Surface Properties ; Water Pollutants, Chemical/isolation & purification
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Substance Nomenclature:: 0 (Cytostatic Agents)
0 (Water Pollutants, Chemical)
15FIX9V2JP (titanium dioxide)
2C6NUM6878 (valrubicin)
55X04QC32I (Sodium Hydroxide)
80168379AG (Doxorubicin)
D1JT611TNE (Titanium)
D58G680W0G (pirarubicin)
DY38VHM5OD (Sodium Hypochlorite)
Entry Date(s):: Date Created: 20191012 Date Completed: 20200310 Latest Revision: 20231104
Update Code:: 20240105
PubMed Central ID:: PMC6788709
DOI:: 10.1371/journal.pone.0223117
PMID:: 31603899
: Czasopismo naukowe

Pełny tekst

Anthracyclines are a class of pharmaceuticals used in cancer treatment have the potential to negatively impact the environment. To study the possibilities of anthracyclines (represented by pirarubicin and valrubicin) removal, chemical inactivation using NaOH (0.01 M) and NaClO (5%) as decontamination agents and adsorption to powdered nanocrystalline titanium dioxide (TiO2) were compared. The titanium dioxide (TiO2) nanoparticles were prepared via homogeneous precipitation of an aqueous solution of titanium (IV) oxy-sulfate (TiOSO4) at different amount (5-120 g) with urea. The as-prepared TiO2 samples were characterized by XRD, HRSEM and nitrogen physisorption. The adsorption process of anthracycline cytostatics was determined followed by high-performance liquid chromatography coupled with mass spectrometry (LC-MS) and an in-situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) technique. It was found that NaClO decomposes anthracyclines to form various transformation products (TPs). No TPs were identified after the reaction of valrubicin with a NaOH solution as well as in the presence of TiO2 nanoparticles. The best degree of removal, 100% of pirarubicin and 85% of valrubicin, has been achieved in a sample with 120 grams of TiOSO4 (TIT120) and TiO2 with 60 grams (TIT60), respectively.
Competing Interests: The authors have declared that no competing interests exist.

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