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Tytuł:
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Delayed Umbilical Cord Clamping is Not Associated with Acute Kidney Injury in Very Low Birth Weight Neonates.
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Autorzy:
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Harer MW; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
McAdams RM; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Conaway M; Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Vergales BD; Department of Pediatrics, University of Virginia, Charlottesville, Virginia.
Hyatt DM; Department of Pediatrics, University of Virginia, Charlottesville, Virginia.
Charlton JR; Department of Pediatrics, University of Virginia, Charlottesville, Virginia.
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Źródło:
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American journal of perinatology [Am J Perinatol] 2020 Jan; Vol. 37 (2), pp. 210-215. Date of Electronic Publication: 2019 Oct 13.
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Typ publikacji:
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Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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Język:
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English
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Imprint Name(s):
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Original Publication: New York, NY : Thieme-Stratton, 1983-
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MeSH Terms:
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Constriction*
Infant, Very Low Birth Weight*/blood
Umbilical Cord*
Acute Kidney Injury/*prevention & control
Infant, Premature, Diseases/*prevention & control
Acute Kidney Injury/etiology ; Female ; Hematocrit ; Humans ; Infant, Newborn ; Infant, Premature/blood ; Infant, Premature, Diseases/etiology ; Male ; Retrospective Studies ; Time Factors
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Grant Information:
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R01 DK110622 United States DK NIDDK NIH HHS; R01 DK111861 United States DK NIDDK NIH HHS
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Entry Date(s):
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Date Created: 20191014 Date Completed: 20200728 Latest Revision: 20200728
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Update Code:
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20240105
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DOI:
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10.1055/s-0039-1697671
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PMID:
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31606889
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Objective: This study aimed to determine if delayed cord clamping (DCC) is associated with a reduction in neonatal acute kidney injury (AKI).
Study Design: A retrospective single-center cohort study of 278 very low birth weight (VLBW) neonates was performed to compare the incidence of AKI in the following groups: immediate cord clamping (ICC), DCC, and umbilical cord milking. AKI was diagnosed by the modified neonatal Kidney Diseases and Improving Global Outcomes (KDIGO) definition.
Results: The incidence of AKI in the first week was 20.1% with no difference between groups ( p = 0.78). After adjustment for potential confounders, the odds of developing AKI, following DCC, compared with ICC was 0.93 (confidence interval [CI]: 0.46-1.86) with no reduction in the stage of AKI between groups.
Conclusion: In this study, DCC was not associated with a reduced rate of AKI in VLBW neonates. However, the data suggest that DCC is also not harmful to the kidneys, further supporting the safety of DCC in VLBW neonates.
Competing Interests: J.R.C. is co-owner of Sindri Technologies, LLC.
(Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
