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Tytuł pozycji:

Molecular Tweezers-like Calix[4]arene Based Alkaline Earth Metal Cation (Ca 2+ , Sr 2+ , and Ba 2+ ) Chemosensor and Its Imaging in Living Cells and Zebrafish.

Tytuł:
Molecular Tweezers-like Calix[4]arene Based Alkaline Earth Metal Cation (Ca ) Chemosensor and Its Imaging in Living Cells and Zebrafish.
Autorzy:
Fang JA; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, School of Chemistry and Chemical Engineering , Guizhou University , Guiyang 550025 , China.
Zhao JL; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
Liao X; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, School of Chemistry and Chemical Engineering , Guizhou University , Guiyang 550025 , China.
Zeng X; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, School of Chemistry and Chemical Engineering , Guizhou University , Guiyang 550025 , China.
Chen K; Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering , Nanjing University of Information Science & Technology , Nanjing 210044 , China.
Wei XY; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
Su SB; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
Luo QY; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
Redshaw C; Department of Chemistry & Biochemistry , University of Hull , Hull HU6 7RX , U.K.
Jin Z; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
Źródło:
Inorganic chemistry [Inorg Chem] 2019 Nov 04; Vol. 58 (21), pp. 14720-14727. Date of Electronic Publication: 2019 Oct 15.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: [Easton, Pa.] American Chemical Society.
MeSH Terms:
Optical Imaging*
Barium/*analysis
Calcium/*analysis
Calixarenes/*chemistry
Metals, Alkaline Earth/*chemistry
Organometallic Compounds/*chemistry
Phenols/*chemistry
Strontium/*analysis
Animals ; Cell Survival ; HeLa Cells ; Humans ; Organometallic Compounds/chemical synthesis ; Tumor Cells, Cultured ; Zebrafish
Substance Nomenclature:
0 (Metals, Alkaline Earth)
0 (Organometallic Compounds)
0 (Phenols)
0 (calix(4)arene)
130036-26-9 (Calixarenes)
24GP945V5T (Barium)
SY7Q814VUP (Calcium)
YZS2RPE8LE (Strontium)
Entry Date(s):
Date Created: 20191016 Date Completed: 20191127 Latest Revision: 20191127
Update Code:
20240105
DOI:
10.1021/acs.inorgchem.9b02364
PMID:
31613605
Czasopismo naukowe
Although alkaline earth metal cations play an important role in our daily life, little attention has been paid to the field of fast quantitative analysis of their content due to a lack of satisfactory precision and a fast and convenient means of detection. In this study, we have designed a set of molecular tweezers based on the calix[4]arene chemosensor L , which was found to exhibit high selectivity and sensitivity toward Ca 2+ , Sr 2+ , and Ba 2+ (by UV-vis and fluorescence methods) with low detection limits of the order of 10 -7 to 10 -8 M and high association constants (of the order of 10 6 ). More significantly, sensor L not only can recognize Ca 2+ , Sr 2+ , and Ba 2+ but also can further discriminate between these three cations via the differing red shifts in their UV-vis spectra (560 nm for L ·Ca 2+ , 570 nm for L ·Sr 2+ , and 580 nm for L ·Ba 2+ complex) which is attributed to their different atomic radii. A rare synergistic effect for the recognition mechanism has been demonstrated by 1 H NMR spectroscopic titration. Sensor L constructed a high shielding field by the cooperation of Tris with alkaline earth metal ion after complex. Additionally, the presence of acetoxymethyl group in sensor L results in enhancement of cell permeability, and as a consequence, sensor L exhibited excellent sensing and imaging ( in vivo ) in living cells and in zebrafish.

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