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Tytuł:
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Molecular Tweezers-like Calix[4]arene Based Alkaline Earth Metal Cation (Ca ) Chemosensor and Its Imaging in Living Cells and Zebrafish.
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Autorzy:
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Fang JA; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, School of Chemistry and Chemical Engineering , Guizhou University , Guiyang 550025 , China.
Zhao JL; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
Liao X; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, School of Chemistry and Chemical Engineering , Guizhou University , Guiyang 550025 , China.
Zeng X; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, School of Chemistry and Chemical Engineering , Guizhou University , Guiyang 550025 , China.
Chen K; Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering , Nanjing University of Information Science & Technology , Nanjing 210044 , China.
Wei XY; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
Su SB; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
Luo QY; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
Redshaw C; Department of Chemistry & Biochemistry , University of Hull , Hull HU6 7RX , U.K.
Jin Z; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen 518055 , China.
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Źródło:
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Inorganic chemistry [Inorg Chem] 2019 Nov 04; Vol. 58 (21), pp. 14720-14727. Date of Electronic Publication: 2019 Oct 15.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: [Easton, Pa.] American Chemical Society.
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MeSH Terms:
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Optical Imaging*
Barium/*analysis
Calcium/*analysis
Calixarenes/*chemistry
Metals, Alkaline Earth/*chemistry
Organometallic Compounds/*chemistry
Phenols/*chemistry
Strontium/*analysis
Animals ; Cell Survival ; HeLa Cells ; Humans ; Organometallic Compounds/chemical synthesis ; Tumor Cells, Cultured ; Zebrafish
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Substance Nomenclature:
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0 (Metals, Alkaline Earth)
0 (Organometallic Compounds)
0 (Phenols)
0 (calix(4)arene)
130036-26-9 (Calixarenes)
24GP945V5T (Barium)
SY7Q814VUP (Calcium)
YZS2RPE8LE (Strontium)
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Entry Date(s):
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Date Created: 20191016 Date Completed: 20191127 Latest Revision: 20191127
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Update Code:
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20240105
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DOI:
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10.1021/acs.inorgchem.9b02364
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PMID:
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31613605
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Although alkaline earth metal cations play an important role in our daily life, little attention has been paid to the field of fast quantitative analysis of their content due to a lack of satisfactory precision and a fast and convenient means of detection. In this study, we have designed a set of molecular tweezers based on the calix[4]arene chemosensor L , which was found to exhibit high selectivity and sensitivity toward Ca 2+ , Sr 2+ , and Ba 2+ (by UV-vis and fluorescence methods) with low detection limits of the order of 10 -7 to 10 -8 M and high association constants (of the order of 10 6 ). More significantly, sensor L not only can recognize Ca 2+ , Sr 2+ , and Ba 2+ but also can further discriminate between these three cations via the differing red shifts in their UV-vis spectra (560 nm for L ·Ca 2+ , 570 nm for L ·Sr 2+ , and 580 nm for L ·Ba 2+ complex) which is attributed to their different atomic radii. A rare synergistic effect for the recognition mechanism has been demonstrated by 1 H NMR spectroscopic titration. Sensor L constructed a high shielding field by the cooperation of Tris with alkaline earth metal ion after complex. Additionally, the presence of acetoxymethyl group in sensor L results in enhancement of cell permeability, and as a consequence, sensor L exhibited excellent sensing and imaging ( in vivo ) in living cells and in zebrafish.