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Tytuł:
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Cys 2 His 2 Zinc Finger Methyl-CpG Binding Proteins: Getting a Handle on Methylated DNA.
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Autorzy:
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Hodges AJ; Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, 84112, USA.
Hudson NO; Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, 84112, USA.
Buck-Koehntop BA; Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, 84112, USA. Electronic address: .
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Źródło:
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Journal of molecular biology [J Mol Biol] 2020 Mar 13; Vol. 432 (6), pp. 1640-1660. Date of Electronic Publication: 2019 Oct 16.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: 1959- : London : Academic Press
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Contributed Indexing:
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Keywords: DNA methylation; Epigenetics; Protein–DNA interactions; Zinc finger methyl-CpG binding proteins
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Entry Date(s):
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Date Created: 20191020 Latest Revision: 20230606
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Update Code:
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20240105
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DOI:
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10.1016/j.jmb.2019.09.012
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PMID:
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31628952
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DNA methylation is an essential epigenetic modification involved in the maintenance of genomic stability, preservation of cellular identity, and regulation of the transcriptional landscape needed to maintain cellular function. In an increasing number of disease conditions, DNA methylation patterns are inappropriately distributed in a manner that supports the disease phenotype. Methyl-CpG binding proteins (MBPs) are specialized transcription factors that read and translate methylated DNA signals into recruitment of protein assemblies that can alter local chromatin architecture and transcription. MBPs thus play a key intermediary role in gene regulation for both normal and diseased cells. Here, we highlight established and potential structure-function relationships for the best characterized members of the zinc finger (ZF) family of MBPs in propagating DNA methylation signals into downstream cellular responses. Current and future investigations aimed toward expanding our understanding of ZF MBP cellular roles will provide needed mechanistic insight into normal and disease state functions, as well as afford evaluation for the potential of these proteins as epigenetic-based therapeutic targets.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)