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Tytuł:
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Target-triggered, self-powered DNAzyme-MnO 2 nanosystem: towards imaging microRNAs in living cells.
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Autorzy:
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Cui MR; State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. .
Li XL; State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. .
Xu JJ; State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. .
Chen HY; State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. .
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Źródło:
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Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Nov 05; Vol. 55 (89), pp. 13366-13369.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Cambridge : Royal Society of Chemistry
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MeSH Terms:
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Cell Survival*
Optical Imaging*
DNA, Catalytic/*chemistry
Manganese Compounds/*chemistry
MicroRNAs/*analysis
Nanoparticles/*chemistry
Oxides/*chemistry
Cell Line, Tumor ; DNA, Catalytic/metabolism ; HeLa Cells ; Humans ; MCF-7 Cells ; Manganese Compounds/metabolism ; Nanoparticles/metabolism ; Oxides/metabolism
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Substance Nomenclature:
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0 (DNA, Catalytic)
0 (Manganese Compounds)
0 (MicroRNAs)
0 (Oxides)
TF219GU161 (manganese dioxide)
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Entry Date(s):
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Date Created: 20191022 Date Completed: 20191111 Latest Revision: 20200108
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Update Code:
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20240105
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DOI:
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10.1039/c9cc06623c
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PMID:
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31631205
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A target-triggered, self-powered strategy for in situ monitoring of intracellular microRNAs was fabricated via a versatile DNAzyme-MnO2 nanosystem, which integrates delivery, quenching, target recognition, self-supply of cofactors and signal amplification all in one.