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Tytuł pozycji:

Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation.

Tytuł :
Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation.
Autorzy :
Zhou Z; Department of Pharmaceutical Sciences, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China.
Liu C; Department of Pharmaceutical Sciences, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China.
Wan X; Department of Pharmaceutical Sciences, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China.
Fang L; Department of Pharmaceutical Sciences, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2020 Jan 01; Vol. 141, pp. 105042. Date of Electronic Publication: 2019 Oct 18.
Typ publikacji :
Journal Article
Język :
English
Journal Info :
Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE
Imprint Name(s) :
Publication: Amsterdam : Elsevier Science B.V
Original Publication: Amsterdam ; New York : Elsevier, c1993-
MeSH Terms :
Ionic Liquids/*administration & dosage
Skin Aging/*drug effects
Thioctic Acid/*administration & dosage
Administration, Cutaneous ; Animals ; Emulsions ; Hydroxyproline/metabolism ; Ionic Liquids/chemistry ; Male ; Rats, Wistar ; Skin/drug effects ; Skin/metabolism ; Skin/radiation effects ; Skin Absorption/drug effects ; Skin Aging/radiation effects ; Thioctic Acid/chemistry ; Ultraviolet Rays/adverse effects
Contributed Indexing :
Keywords: Anti – aging efficacy; Ionic liquids; Skin retention; Solubility; Α – lipoic acid
Substance Nomenclature :
0 (Emulsions)
0 (Ionic Liquids)
73Y7P0K73Y (Thioctic Acid)
RMB44WO89X (Hydroxyproline)
Entry Date(s) :
Date Created: 20191022 Date Completed: 20200416 Latest Revision: 20200416
Update Code :
20200716
DOI :
10.1016/j.ejps.2019.105042
PMID :
31634554
Czasopismo naukowe
Skin aging affects personal image and health. α - lipoic acid (ALA), with excellent free radical scavenging capacity, was used in this research to prepare W/O emulsion. Considering the instability of ALA, ionic liquid strategy was adopted to heighten the solubility of ALA for dissolving in water phase. The mechanism of different ionic liquids (ILs) on skin retention of ALA was investigated by in vitro skin permeation experiment, emulsion quality characterization, rheological test, ATR - FTIR and molecular simulation. The results showed that ionic liquid strategy had a positive influence on the solubilization of ALA. Different ILs were different in skin retention and regulated by skin layers rather than drug release, in which ALA - triethanolamine (ALA - TEOA) presented the best affinity with both stratum corneum (SC) and viable epidermis and dermis (VED), while ALA - N - (2 - Hydroxyethyl) piperidine (ALA - HEPP) as well as ALA - N - (2 - hydroxyethyl) pyrrolidine (ALA - HEPR) showed affinity with either SC or VED respectively. Finally, the emulsion presented brilliant anti - aging efficacy. This study provided a new method of emulsion research and had great significance for the development of topical formulations.
(Copyright © 2019 Elsevier B.V. All rights reserved.)

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