Adult stem cells and regenerative medicine-a symposium report.

Tytuł:: Adult stem cells and regenerative medicine-a symposium report.
Autorzy:: Cable J; Science Writer, New York, New York.
Fuchs E; Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, New York.
Weissman I; Pathology Stem Cell Institute, Stanford University, Stanford, California.
Jasper H; Genentech, San Francisco, California.
Glass D; Novartis, Cambridge, Massachusetts.
Rando TA; Neurology & Neurological Sciences, Stanford University, Stanford, California.
Blau H; Microbiology and Immunology - Baxter Labs, Stanford University, Stanford, California.
Debnath S; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York.
Oliva A; Longeveron, Miami, Florida.
Park S; Department of Genetics, Yale University, New Haven, Connecticut.
Passegué E; Columbia Stem Cell Initiative, Department of Genetics & Development, Columbia University, New York, New York.
Kim C; Dana Farber/Harvard Cancer Center, Boston, Massachusetts.; Division of Hematology/Oncology, Stem Cell Program, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.; Genetics Department, Harvard Medical School, Boston, Massachusetts.; Harvard Stem Cell Institute, Cambridge, Massachusetts.
Krasnow MA; Department of Biochemistry, Stanford University, Stanford, California.
Źródło:: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Feb; Vol. 1462 (1), pp. 27-36. Date of Electronic Publication: 2019 Oct 26.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Język:: English
Imprint Name(s):: Publication: 2006- : New York, NY : Malden, MA : New York Academy of Sciences ; Blackwell
Original Publication: New York, The Academy.
MeSH Terms:: Adult Stem Cells/*transplantation
Regenerative Medicine/*trends
Research Report/*trends
Stem Cell Transplantation/*trends
Adult ; Adult Stem Cells/physiology ; Aging/pathology ; Animals ; Cell Differentiation/physiology ; Humans ; Neoplasms/pathology ; Neoplasms/therapy ; New York City ; Regenerative Medicine/methods ; Stem Cell Transplantation/methods
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Grant Information:: UM1 HL113460 United States HL NHLBI NIH HHS; P2C HD086843 United States HD NICHD NIH HHS; R01 HL125821 United States HL NHLBI NIH HHS; R01 AR073248 United States AR NIAMS NIH HHS; DP5 OD021351 United States OD NIH HHS; R42 AG054322 United States AG NIA NIH HHS; R44 AG062015 United States AG NIA NIH HHS; R01 HL132266 United States HL NHLBI NIH HHS; I01 RX001222 United States RX RRD VA; R01 AG055755 United States AG NIA NIH HHS
Contributed Indexing:: Keywords: adult stem cells; age-related degeneration; aging; differentiation; epidermal stem cells; hematopoietic stem cells; immune-stem cell interactions; inflammation; lung stem cells; mesenchymal cells; muscle stem cells; regenerative medicine; stem cell niche; stem cell signaling; tissue regeneration; tumor stem cells
Entry Date(s):: Date Created: 20191027 Date Completed: 20200708 Latest Revision: 20200911
Update Code:: 20240104
PubMed Central ID:: PMC7135961
DOI:: 10.1111/nyas.14243
PMID:: 31655007
: Czasopismo naukowe

Pełny tekst

Adult stem cells are rare, undifferentiated cells found in all tissues of the body. Although normally kept in a quiescent, nondividing state, these cells can proliferate and differentiate to replace naturally dying cells within their tissue and to repair its wounds in response to injury. Due to their proliferative nature and ability to regenerate tissue, adult stem cells have the potential to treat a variety of degenerative diseases as well as aging. In addition, since stem cells are often thought to be the source of malignant tumors, understanding the mechanisms that keep their proliferative abilities in check can pave the way for new cancer therapies. While adult stem cells have had limited practical and clinical applications to date, several clinical trials of stem cell-based therapies are underway. This report details recent research presented at the New York Academy of Sciences on March 14, 2019 on understanding the factors that regulate stem cell activity and differentiation, with the hope of translating these findings into the clinic.
(© 2019 New York Academy of Sciences.)

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