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Tytuł:
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An uncommon neurological manifestation of chronic lymphocytic leukemia: Longitudinally extensive transverse myelitis.
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Autorzy:
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Akdogan O; Istanbul Training and Research Hospital, Neurology Department, Turkey.
Guven T; Istanbul Training and Research Hospital, Neurology Department, Turkey.
Altindal S; Istanbul Training and Research Hospital, Hematology Department, Turkey.
Erdal Y; Istanbul Training and Research Hospital, Neurology Department, Turkey. Electronic address: .
Emre U; Istanbul Training and Research Hospital, Neurology Department, Turkey.
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Źródło:
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Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2020 Jan; Vol. 37, pp. 101455. Date of Electronic Publication: 2019 Oct 23.
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Typ publikacji:
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Case Reports
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Język:
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English
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Imprint Name(s):
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Original Publication: [Amsterdam] : Elsevier B. V.
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MeSH Terms:
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Leukemia, Lymphocytic, Chronic, B-Cell/*diagnosis
Myelitis, Transverse/*diagnosis
Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Myelitis, Transverse/etiology
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Contributed Indexing:
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Keywords: Chronic lymphocytic leukemia; Spinal cord; Transverse myelitis
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Entry Date(s):
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Date Created: 20191101 Date Completed: 20201118 Latest Revision: 20201118
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Update Code:
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20240104
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DOI:
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10.1016/j.msard.2019.101455
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PMID:
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31670207
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We describe a 50-year-old male patient who was admitted to the emergency department with complaints of fever and fatigue that had suddenly started two weeks ago. In the laboratory evaluation, a white blood cell count of 131.000/mm 3 was detected. The patient was hospitalized and developed fecal incontinence on the first day of hospitalization. Detailed neurological examination revealed the patient had tetraparesis. Long segment high signal intensity was observed on spinal MRI. Flow cytometry examination of the CSF and biopsy findings of the bone marrow were compatible with Chronic Lymphocytic Leukemia (CLL). The patient's MRI appearances resolved after treatment. The tetraparesis resolved partially. There was no motor deficit in upper extremities and the patient was able to walk without aid or rest for 100 m. Clinical manifestation of central nervous system (CNS) involvement in CLL is heterogeneous and therefore may be difficult to pinpoint. We have described an uncommon occurrence of CNS involvement in CLL.
Competing Interests: Declaration of Competing Interest The authors declare that there is no conflict of interest.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
