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Tytuł:
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Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability.
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Autorzy:
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Caritá AC; Department of Translational Medicine-Federal University of São Paulo, Brazil. Electronic address: .
Fonseca-Santos B; Department of Drugs and Medicines - School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, SP, Brazil.
Shultz JD; Department of Translational Medicine-Federal University of São Paulo, Brazil; Department of Drugs and Medicines - School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, SP, Brazil; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, USA.
Michniak-Kohn B; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, USA.
Chorilli M; Department of Drugs and Medicines - School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, SP, Brazil.
Leonardi GR; College of Pharmaceutical Sciences-Campinas State University, Brazil.
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Źródło:
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Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2020 Feb; Vol. 24, pp. 102117. Date of Electronic Publication: 2019 Oct 30.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: New York, NY : Elsevier, c2005-
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MeSH Terms:
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Antioxidants*/chemistry
Antioxidants*/therapeutic use
Ascorbic Acid*/chemistry
Ascorbic Acid*/therapeutic use
Drug Delivery Systems*
Nanostructures*/chemistry
Nanostructures*/therapeutic use
Vitamins*/chemistry
Vitamins*/therapeutic use
Chemistry, Pharmaceutical ; Drug Stability
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Contributed Indexing:
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Keywords: Ascorbic acid; Drug delivery; Liposomes; Microemulsions; Nanoparticles; Targeting
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Substance Nomenclature:
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0 (Antioxidants)
0 (Vitamins)
PQ6CK8PD0R (Ascorbic Acid)
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Entry Date(s):
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Date Created: 20191103 Date Completed: 20201112 Latest Revision: 20201112
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Update Code:
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20240104
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DOI:
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10.1016/j.nano.2019.102117
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PMID:
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31676375
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Vitamin C (Vit C) is a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. However, the biggest challenge in the utilization of Vit C is to maintain its stability and improve its delivery to the active site. Several strategies have been developed such as: controlling the oxygen levels during formulation and storage, low pH, reduction of water content in the formulation and the addition of preservative agents. Additionally, the utilization of derivatives of Vit C and the development of micro and nanoencapsulated delivery systems have been highlighted. In this article, the multiple applications and mechanisms of action of vitamin C will be reviewed and discussed, as well as the new possibilities of delivery and improvement of stability.
(Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.)
