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Tytuł pozycji:

Isolated leptomeningeal carcinomatosis and possible fungal meningitis as late sequelae of oesophageal adenocarcinoma.

Tytuł:
Isolated leptomeningeal carcinomatosis and possible fungal meningitis as late sequelae of oesophageal adenocarcinoma.
Autorzy:
Dumbill R; General Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK .
Thompson S; Department of Clinical Geratology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Peschl H; Cardiothoracic Radiology and Emergency Imaging, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Turner G; Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Woodrow C; Department of Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Źródło:
BMJ case reports [BMJ Case Rep] 2019 Nov 02; Vol. 12 (11). Date of Electronic Publication: 2019 Nov 02.
Typ publikacji:
Case Reports; Journal Article
Język:
English
Imprint Name(s):
Original Publication: London : BMJ Pub. Group
MeSH Terms:
Meningeal Carcinomatosis/*complications
Meningeal Carcinomatosis/*secondary
Meningitis, Fungal/*complications
Adenocarcinoma/therapy ; Aged ; Brain/diagnostic imaging ; Brain/pathology ; Cladosporium/isolation & purification ; Confusion/etiology ; Diagnosis, Differential ; Esophageal Neoplasms/therapy ; Exophiala/isolation & purification ; Fatal Outcome ; Humans ; Magnetic Resonance Imaging ; Male ; Meningeal Carcinomatosis/cerebrospinal fluid ; Meningeal Carcinomatosis/diagnosis ; Meningitis, Fungal/cerebrospinal fluid ; Meningitis, Fungal/diagnosis
References:
BMJ Case Rep. 2016 Jan 06;2016:. (PMID: 26740266)
BMJ Case Rep. 2013 Apr 19;2013:. (PMID: 23606394)
BMJ Case Rep. 2013 Jan 21;2013:. (PMID: 23341584)
BMJ Case Rep. 2013 Apr 16;2013:. (PMID: 23595172)
Eur Arch Otorhinolaryngol. 2016 Sep;273(9):2481-6. (PMID: 26645106)
Clin Infect Dis. 2014 Mar;58(5):622-30. (PMID: 24336827)
Korean J Pathol. 2013 Dec;47(6):563-8. (PMID: 24421850)
Contributed Indexing:
Keywords: meningitis; oesophageal cancer; pathology; surgical oncology
SCR Disease Name:
Adenocarcinoma Of Esophagus
Entry Date(s):
Date Created: 20191104 Date Completed: 20200326 Latest Revision: 20211103
Update Code:
20240104
PubMed Central ID:
PMC6827809
DOI:
10.1136/bcr-2019-230117
PMID:
31678919
Czasopismo naukowe
We describe a case of a 67-year-old man with known chronic obstructive pulmonary disease, type 2 diabetes mellitus, hypertension, osteoarthritis, previous history of excess alcohol intake, and oesophagectomy 3 years earlier for T3N0 adenocarcinoma, referred by his general practitioner with confusion, weight loss and several recent falls. CT of the chest, abdomen and pelvis revealed a right middle-lobe pulmonary embolism, while CT of the head revealed a communicating hydrocephalus. Lumbar puncture was performed, and empirical treatment for tuberculous and fungal meningitis was commenced. Unfortunately, he suffered a rapid neurological deterioration with markedly elevated cerebrospinal fluid (CSF) pressures, leading to an external ventricular drain. Cytological analysis of a CSF sample revealed a cellular infiltrate consistent with leptomeningeal carcinomatosis (adenocarcinoma), with the previous oesophageal malignancy the likely primary. He passed away 17 days after hospital admission. Prolonged culture of CSF later produced evidence of two distinct phaeomycotic moulds ( Cladosporium sp and Exophiala sp), suggesting that fungal meningitis may also have contributed to the clinical picture.
Competing Interests: Competing interests: None declared.
(© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)

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