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Tytuł pozycji:

Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats.

Tytuł :
Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats.
Autorzy :
Freire JMO; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Chaves HV; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Teixeira AH; School of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil.
de Sousa LHT; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Pinto IR; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Costa JJDN; School of Medicine, University CenterINTA-UNINTA, Sobral, Ceará, Brazil.
de Sousa NA; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Pereira KMA; Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Girão VCC; Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Ferreira VCS; Postgraduate Program in Morphofunctional Sciences, Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Dos Santos JEÁ; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Lima MAS; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Pimenta ATA; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Montenegro RC; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Moraes MEA; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Pinto VPT; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Filho GC; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Bezerra MM; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
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Źródło :
PloS one [PLoS One] 2019 Nov 04; Vol. 14 (11), pp. e0223800. Date of Electronic Publication: 2019 Nov 04 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Inflammation/*drug therapy
Periodontitis/*drug therapy
Plant Extracts/*pharmacology
Protective Agents/*pharmacology
Trees/*chemistry
Animals ; Female ; Gingiva/drug effects ; Gingiva/metabolism ; Inflammation/metabolism ; Oxidative Stress/drug effects ; Periodontitis/metabolism ; Plant Leaves/chemistry ; Rats ; Rats, Wistar ; Transcription, Genetic/drug effects
References :
Anal Biochem. 1971 Nov;44(1):276-87. (PMID: 4943714)
Immunology. 2001 Jul;103(3):255-61. (PMID: 11454054)
Methods Biochem Anal. 1954;1:357-424. (PMID: 13193536)
J Periodontol. 2000 Jun;71(6):1009-14. (PMID: 10914805)
J Clin Diagn Res. 2013 Jun;7(6):1223-7. (PMID: 23905146)
J Nat Prod. 2005 Mar;68(3):423-6. (PMID: 15787450)
Clin Oral Investig. 2018 Jul;22(6):2175-2185. (PMID: 29288400)
Front Physiol. 2017 Dec 01;8:988. (PMID: 29249988)
Proteomics Clin Appl. 2014 Oct;8(9-10):748-61. (PMID: 24828325)
Life Sci. 2006 Apr 11;78(20):2409-17. (PMID: 16316665)
Dis Markers. 2013;34(5):305-11. (PMID: 23478273)
Eur J Pain. 2014 Oct;18(9):1280-9. (PMID: 24715714)
Ann N Y Acad Sci. 2010 Mar;1192:190-200. (PMID: 20392236)
J Clin Periodontol. 2013 Dec;40(12):1112-7. (PMID: 24118119)
Innate Immun. 2014 Jul;20(5):511-8. (PMID: 24045341)
Antioxidants (Basel). 2015 Jun 24;4(3):447-81. (PMID: 26783837)
Blood. 1982 Sep;60(3):618-22. (PMID: 6286012)
J Periodontol. 2017 Feb;88(2):190-196. (PMID: 27739344)
Mini Rev Med Chem. 2014;14(14):1169-82. (PMID: 25553429)
J Periodontal Res. 2004 Apr;39(2):101-6. (PMID: 15009517)
J Periodontol. 2011 Jan;82(1):122-8. (PMID: 20722535)
J Immunol. 1988 Oct 1;141(7):2407-12. (PMID: 3139757)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
Clin Chim Acta. 1975 Mar 24;59(3):361-7. (PMID: 1126023)
Biomed Pharmacother. 2018 Feb;98:863-872. (PMID: 29571257)
J Clin Periodontol. 2012 Mar;39(3):239-48. (PMID: 22092994)
PLoS One. 2016 Apr 26;11(4):e0153716. (PMID: 27116554)
J Periodontol. 2008 Sep;79(9):1719-25. (PMID: 18771374)
Oral Dis. 2012 Jan;18(1):32-9. (PMID: 21851508)
J Appl Oral Sci. 2018 Jul 16;26:e20170266. (PMID: 30020350)
Mol Oral Microbiol. 2014 Dec;29(6):248-57. (PMID: 24976068)
Substance Nomenclature :
0 (Anti-Inflammatory Agents)
0 (Plant Extracts)
0 (Protective Agents)
Entry Date(s) :
Date Created: 20191105 Date Completed: 20200313 Latest Revision: 20200313
Update Code :
20201218
PubMed Central ID :
PMC6827912
DOI :
10.1371/journal.pone.0223800
PMID :
31682614
Czasopismo naukowe
Periodontitis is an immuno-inflammatory disease, which can lead to tooth loss. This study aimed to investigate the efficacy of Platymiscium floribundum Vog., a Brazilian tree which has been used in folk medicine as an anti-inflammatory agent, in a pre-clinical trial of periodontitis in rats. Periodontitis was induced by placing a sterilized nylon (3.0) thread ligature around the cervix of the second left upper molar of the rats, which received (per os) P. floribundum extract (0.1, 1 or 10 mg/kg) or vehicle 1h before periodontitis-challenge and once daily during 11 days. Treatment with P. floribundum (10mg/kg) decreased alveolar bone loss, MPO activity nitrite/nitrate levels, oxidative stress, TNF-α, IL1-β, IL-8/CINC-1, and PGE2 gingival levels, and transcription of TNF-α, IL1-β, COX-2, iNOS, RANK, and RANKL genes, while elevated both BALP serum levels and IL-10 gingival levels. The animals did not show signs of toxicity throughout the experimental course. These findings show that P. floribundum has anti-inflammatory and anti-resorptive properties in a pre-clinical trial of periodontitis, representing an interesting biotechnological tool.
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