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Tytuł:
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Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats.
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Autorzy:
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Freire JMO; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Chaves HV; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Teixeira AH; School of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil.
de Sousa LHT; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Pinto IR; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Costa JJDN; School of Medicine, University CenterINTA-UNINTA, Sobral, Ceará, Brazil.
de Sousa NA; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Pereira KMA; Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Girão VCC; Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Ferreira VCS; Postgraduate Program in Morphofunctional Sciences, Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Dos Santos JEÁ; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Lima MAS; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Pimenta ATA; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Montenegro RC; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Moraes MEA; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Pinto VPT; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Filho GC; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Bezerra MM; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
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Źródło:
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PloS one [PLoS One] 2019 Nov 04; Vol. 14 (11), pp. e0223800. Date of Electronic Publication: 2019 Nov 04 (Print Publication: 2019).
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: San Francisco, CA : Public Library of Science
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MeSH Terms:
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Anti-Inflammatory Agents/*pharmacology
Inflammation/*drug therapy
Periodontitis/*drug therapy
Plant Extracts/*pharmacology
Protective Agents/*pharmacology
Trees/*chemistry
Animals ; Female ; Gingiva/drug effects ; Gingiva/metabolism ; Inflammation/metabolism ; Oxidative Stress/drug effects ; Periodontitis/metabolism ; Plant Leaves/chemistry ; Rats ; Rats, Wistar ; Transcription, Genetic/drug effects
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References:
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Substance Nomenclature:
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0 (Anti-Inflammatory Agents)
0 (Plant Extracts)
0 (Protective Agents)
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Entry Date(s):
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Date Created: 20191105 Date Completed: 20200313 Latest Revision: 20200313
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Update Code:
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20240104
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PubMed Central ID:
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PMC6827912
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DOI:
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10.1371/journal.pone.0223800
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PMID:
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31682614
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Periodontitis is an immuno-inflammatory disease, which can lead to tooth loss. This study aimed to investigate the efficacy of Platymiscium floribundum Vog., a Brazilian tree which has been used in folk medicine as an anti-inflammatory agent, in a pre-clinical trial of periodontitis in rats. Periodontitis was induced by placing a sterilized nylon (3.0) thread ligature around the cervix of the second left upper molar of the rats, which received (per os) P. floribundum extract (0.1, 1 or 10 mg/kg) or vehicle 1h before periodontitis-challenge and once daily during 11 days. Treatment with P. floribundum (10mg/kg) decreased alveolar bone loss, MPO activity nitrite/nitrate levels, oxidative stress, TNF-α, IL1-β, IL-8/CINC-1, and PGE2 gingival levels, and transcription of TNF-α, IL1-β, COX-2, iNOS, RANK, and RANKL genes, while elevated both BALP serum levels and IL-10 gingival levels. The animals did not show signs of toxicity throughout the experimental course. These findings show that P. floribundum has anti-inflammatory and anti-resorptive properties in a pre-clinical trial of periodontitis, representing an interesting biotechnological tool.
Competing Interests: The authors have declared that no competing interests exist.
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