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Tytuł:
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The first case of gland inclusion in an intrapulmonary lymph node: a mimic of metastasis.
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Autorzy:
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Wang C; Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, 6 Seventh Panxi Branch Road, Jiangbei District, Chongqing, 400021, China.
Cao Y; Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, 6 Seventh Panxi Branch Road, Jiangbei District, Chongqing, 400021, China.
Zeng M; Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, 6 Seventh Panxi Branch Road, Jiangbei District, Chongqing, 400021, China.
Wang L; Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, 6 Seventh Panxi Branch Road, Jiangbei District, Chongqing, 400021, China.
Cao X; Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, 6 Seventh Panxi Branch Road, Jiangbei District, Chongqing, 400021, China.
Zou L; Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, 6 Seventh Panxi Branch Road, Jiangbei District, Chongqing, 400021, China.
Cao Y; Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, 6 Seventh Panxi Branch Road, Jiangbei District, Chongqing, 400021, China. .; Department of Pathology, College of Basic Medicine, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China. .
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Źródło:
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World journal of surgical oncology [World J Surg Oncol] 2019 Nov 04; Vol. 17 (1), pp. 181. Date of Electronic Publication: 2019 Nov 04.
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Typ publikacji:
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Case Reports; Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: London : BioMed Central, 2003-
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MeSH Terms:
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Adenocarcinoma of Lung/*diagnosis
Biomarkers, Tumor/*analysis
Lung Neoplasms/*diagnosis
Lymph Nodes/*pathology
Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/surgery ; Adult ; Biopsy, Fine-Needle ; Diagnosis, Differential ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Lymph Node Excision ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/surgery ; Lymphatic Metastasis/diagnosis ; Male ; Pneumonectomy ; Tomography, X-Ray Computed ; Treatment Outcome
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References:
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Am J Clin Pathol. 1990 Jun;93(6):741-8. (PMID: 2161177)
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Grant Information:
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2012-1-79 the Key Project of Chongqing Municipal Health Bureau, China
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Contributed Indexing:
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Keywords: Epithelial inclusion; Lung adenocarcinoma; Lymph node; Metastasis; Tumour staging
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Substance Nomenclature:
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0 (Biomarkers, Tumor)
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Entry Date(s):
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Date Created: 20191106 Date Completed: 20200427 Latest Revision: 20200427
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Update Code:
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20240104
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PubMed Central ID:
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PMC6829919
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DOI:
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10.1186/s12957-019-1726-1
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PMID:
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31684955
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Background: Lymph node inclusions are foci of ectopic tissue in lymph nodes, which were reported in different areas of the body. However, inclusions in the mediastinal lymph node are rare. Here, we report the first case of glandular inclusion within the parenchyma of the intrapulmonary lymph node in a patient with primary lung adenocarcinoma.
Case Presentation: A computed tomography (CT) scan showed a solid pulmonary nodule in the right upper lobe in a 44-year-old man. After a fine needle aspiration biopsy diagnosis of adenocarcinoma, lobectomy and lymph dissection were performed. Histological sections of the lung demonstrated a papillary predominant adenocarcinoma and one intrapulmonary lymph node, which displayed glandular inclusion occupying the node parenchyma. The gland inclusion was very similar to metastasis, but was formed by two layers of epithelial cells, and the abluminal cells were positive for P63, P40, and CK5/6. The patient has remained alive without recurrence and metastasis at the last follow-up before publication.
Conclusions: It is very important to correctly diagnose a lymph node inclusion for proper clinical management.
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