Neutropenic enterocolitis: A clinico-pathological review.

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Abstrakt

Tytuł:: Neutropenic enterocolitis: A clinico-pathological review.
Autorzy:: Xia R; Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, United States.
Zhang X; Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, United States. .
Źródło:: World journal of gastrointestinal pathophysiology [World J Gastrointest Pathophysiol] 2019 Oct 15; Vol. 10 (3), pp. 36-41.
Typ publikacji:: Editorial
Język:: English
Imprint Name(s):: Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group
Original Publication: Beijing, China : Beijing Baishideng BioMed Scientifc Company
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Contributed Indexing:: Keywords: Chemotherapy; Neutropenia; Neutropenic enterocolitis; Typhlitis
Entry Date(s):: Date Created: 20191107 Latest Revision: 20200928
Update Code:: 20240104
PubMed Central ID:: PMC6829094
DOI:: 10.4291/wjgp.v10.i3.36
PMID:: 31692935
: Opinia redakcyjna

Neutropenic enterocolitis (NE) is a predominantly cecum-based disease with high mortality seen in patients post chemotherapy. The pathogenesis of NE is poorly understood and probably multifactorial involving mucosal injury, neutropenia, and impaired host defense to intestinal organisms. The clinical presentation is characterized as ileocolonic inflammation and bowel wall thickening in patients with neutropenia, fever, and abdominal pain. The pathological features of NE include patchy necrosis, hemorrhage, ulcer, edema, perforation, infiltrating organisms, and characteristically, depletion of inflammatory cells (neutrophils). NE should always be considered as a possible diagnosis in immunosuppressed patients, especially those receiving chemotherapy. High clinical and histological diagnostic discordance rate exists. High index of clinical suspicion and prompt appropriate personalized management are essential to achieve a lower mortality rate.
Competing Interests: Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
(©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.)

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