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Tytuł pozycji:

E2FB Interacts with RETINOBLASTOMA RELATED and Regulates Cell Proliferation during Leaf Development.

Tytuł:
E2FB Interacts with RETINOBLASTOMA RELATED and Regulates Cell Proliferation during Leaf Development.
Autorzy:
Őszi E; Institute of Plant Biology, Biological Research Centre, Szeged, 6726, Hungary.; Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, 6726, Hungary.
Papdi C; Royal Holloway University of London, School of Biological Sciences, Centre for Systems and Synthetic Biology, Egham, TW20 0EX, United Kingdom.
Mohammed B; Royal Holloway University of London, School of Biological Sciences, Centre for Systems and Synthetic Biology, Egham, TW20 0EX, United Kingdom.
Petkó-Szandtner A; Institute of Plant Biology, Biological Research Centre, Szeged, 6726, Hungary.; Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary.
Leviczky T; Institute of Plant Biology, Biological Research Centre, Szeged, 6726, Hungary.; Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, 6726, Hungary.
Molnár E; Institute of Plant Biology, Biological Research Centre, Szeged, 6726, Hungary.
Galvan-Ampudia C; Laboratoire de Reproduction et Développement des Plantes, Université de Lyon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, F-69364 Lyon, France.
Khan S; Royal Holloway University of London, School of Biological Sciences, Centre for Systems and Synthetic Biology, Egham, TW20 0EX, United Kingdom.
Juez EL; Royal Holloway University of London, School of Biological Sciences, Centre for Systems and Synthetic Biology, Egham, TW20 0EX, United Kingdom.
Horváth B; Royal Holloway University of London, School of Biological Sciences, Centre for Systems and Synthetic Biology, Egham, TW20 0EX, United Kingdom.
Bögre L; Royal Holloway University of London, School of Biological Sciences, Centre for Systems and Synthetic Biology, Egham, TW20 0EX, United Kingdom.
Magyar Z; Institute of Plant Biology, Biological Research Centre, Szeged, 6726, Hungary .
Źródło:
Plant physiology [Plant Physiol] 2020 Jan; Vol. 182 (1), pp. 518-533. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język:
English
Imprint Name(s):
Publication: : [Rockville, MD] : American Society of Plant Biologists
Original Publication: Lancaster, Pa., American Society of Plant Physiologists.
MeSH Terms:
Arabidopsis/*metabolism
Arabidopsis Proteins/*metabolism
E2F Transcription Factors/*metabolism
Plant Leaves/*metabolism
Plants, Genetically Modified/*metabolism
Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; E2F Transcription Factors/genetics ; Gene Expression Regulation, Plant/genetics ; Mutation/genetics ; Plant Leaves/genetics ; Plants, Genetically Modified/genetics ; Promoter Regions, Genetic/genetics
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Grant Information:
BB/M025047/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council
Substance Nomenclature:
0 (Arabidopsis Proteins)
0 (E2F Transcription Factors)
0 (E2Fb protein, Arabidopsis)
Entry Date(s):
Date Created: 20191108 Date Completed: 20201222 Latest Revision: 20210101
Update Code:
20240105
PubMed Central ID:
PMC6945829
DOI:
10.1104/pp.19.00212
PMID:
31694902
Czasopismo naukowe
Cell cycle entry and quiescence are regulated by the E2F transcription factors in association with RETINOBLASTOMA-RELATED (RBR). E2FB is considered to be a transcriptional activator of cell cycle genes, but its function during development remains poorly understood. Here, by studying E2FB-RBR interaction, E2F target gene expression, and epidermal cell number and shape in e2fb mutant and overexpression lines during leaf development in Arabidopsis ( Arabidopsis thaliana ), we show that E2FB in association with RBR plays a role in the inhibition of cell proliferation to establish quiescence. In young leaves, both RBR and E2FB are abundant and form a repressor complex that is reinforced by an autoregulatory loop. Increased E2FB levels, either by expression driven by its own promoter or ectopically together with DIMERIZATION PARTNER A, further elevate the amount of this repressor complex, leading to reduced leaf cell number. Cell overproliferation in e2fb mutants and in plants overexpressing a truncated form of E2FB lacking the RBR binding domain strongly suggested that RBR repression specifically acts through E2FB. The increased number of small cells below the guard cells and of fully developed stomata indicated that meristemoids preferentially hyperproliferate. As leaf development progresses and cells differentiate, the amount of RBR and E2FB gradually declined. At this stage, elevation of E2FB level can overcome RBR repression, leading to reactivation of cell division in pavement cells. In summary, E2FB in association with RBR is central to regulating cell proliferation during organ development to determine final leaf cell number.
(© 2020 The authors. All Rights Reserved.)

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