The association of pre-operative anaemia with survival after orthotopic liver transplantation.

Tytuł:: The association of pre-operative anaemia with survival after orthotopic liver transplantation.
Autorzy:: Lichtenegger P; Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Schiefer J; Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Graf A; Section for Medical Statistics, Centre for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
Berlakovich G; Division of Transplantation, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Faybik P; Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Baron DM; Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Baron-Stefaniak J; Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Źródło:: Anaesthesia [Anaesthesia] 2020 Apr; Vol. 75 (4), pp. 472-478. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: London, Academic Press; New York, Grune & Stratton.
MeSH Terms:: Liver Transplantation*
Anemia/*epidemiology
Postoperative Complications/*epidemiology
Austria/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Preoperative Period ; Risk Factors ; Survival Analysis
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Contributed Indexing:: Keywords: end-stage liver disease; morbidity; mortality; orthotopic liver transplantation; outcome; pre-operative anaemia; transfusion
Entry Date(s):: Date Created: 20191109 Date Completed: 20200316 Latest Revision: 20200320
Update Code:: 20240105
PubMed Central ID:: PMC7078747
DOI:: 10.1111/anae.14918
PMID:: 31701527
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Anaemia is common in patients with end-stage liver disease. Pre-operative anaemia is associated with greater mortality after major surgery. We analysed the association of pre-operative anaemia (World Health Organization classification) with survival and complications after orthotopic liver transplantation using Cox and logistic regression models. We included patients undergoing their first orthotopic liver transplantation between 2004 and 2016. Out of 599 included patients, 455 (76%) were anaemic before transplantation. Pre-operative anaemia was not associated with the survival of 485/599 (81%) patients to 1 year after liver transplantation, OR (95%CI) 1.04 (0.64-1.68), p = 0.88. Pre-operative anaemia was associated with higher rates of intra-operative blood transfusions and acute postoperative kidney injury on multivariable analysis, OR (95%CI) 1.70 (0.82-2.59) and 1.72 (1.11-2.67), respectively, p < 0.001 for both. Postoperative renal replacement therapy was associated with pre-operative anaemia on univariate analysis, OR (95%CI) 1.87 (1.11-3.15), p = 0.018.
(© 2019 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)

Comment in: Anaesthesia. 2020 May;75(5):690. (PMID: 32557530)

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