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Tytuł pozycji:

Measurement of Ocular Compliance Using iPerfusion.

Tytuł:
Measurement of Ocular Compliance Using iPerfusion.
Autorzy:
Sherwood JM; Department of Bioengineering, Imperial College London, London, United Kingdom.
Boazak EM; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.
Feola AJ; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.; Atlanta VA Medical Center, Atlanta, GA, United States.
Parker K; Department of Bioengineering, Imperial College London, London, United Kingdom.
Ethier CR; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Overby DR; Department of Bioengineering, Imperial College London, London, United Kingdom.
Źródło:
Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2019 Oct 25; Vol. 7, pp. 276. Date of Electronic Publication: 2019 Oct 25 (Print Publication: 2019).
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Lausanne : Frontiers Media S.A., [2013]-
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Grant Information:
IK2 RX002342 United States RX RRD VA; R01 EY022359 United States EY NEI NIH HHS; R21 EY026685 United States EY NEI NIH HHS
Contributed Indexing:
Keywords: cornea; glaucoma; ocular compliance; ocular rigidity; sclera
Entry Date(s):
Date Created: 20191112 Latest Revision: 20220122
Update Code:
20240105
PubMed Central ID:
PMC6823226
DOI:
10.3389/fbioe.2019.00276
PMID:
31709244
Czasopismo naukowe
The pressure-volume relationship of the eye is determined by the biomechanical properties of the corneoscleral shell and is classically characterised by Friedenwald's coefficient of ocular rigidity or, alternatively, by the ocular compliance (OC), defined as dV/dP. OC is important in any situation where the volume (V) or pressure (P) of the eye is perturbed, as occurs during several physiological and pathological processes. However, accurately measuring OC is challenging, particularly in rodents. We measured OC in 24 untreated enucleated eyes from 12 C57BL/6 mice using the iPerfusion system to apply controlled pressure steps, whilst measuring the time-varying flow rate into the eye. Pressure and flow data were analysed by a "Discrete Volume" (integrating the flow trace) and "Step Response" method (fitting an analytical solution to the pressure trace). OC evaluated at 13 mmHg was similar between the two methods (Step Response, 41 [37, 46] vs. Discrete Volume, 42 [37, 48] nl/mmHg; mean [95% CI]), although the Step Response Method yielded tighter confidence bounds on individual eyes. OC was tightly correlated between contralateral eyes ( R 2 = 0.75, p = 0.0003). Following treatment with the cross-linking agent genipin, OC decreased by 40 [33, 47]% ( p = 0.0001; N = 6, Step Response Method). Measuring OC provides a powerful tool to assess corneoscleral biomechanics in mice and other species.
(Copyright © 2019 Sherwood, Boazak, Feola, Parker, Ethier and Overby.)

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