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Tytuł pozycji:

Validation of the Radford Nomogram to Estimate the Minute Volume Required to Attain Normocapnia in Patients Undergoing General Anesthesia: A Single-Center Retrospective Study

Tytuł:
Validation of the Radford Nomogram to Estimate the Minute Volume Required to Attain Normocapnia in Patients Undergoing General Anesthesia: A Single-Center Retrospective Study
Autorzy:
Mizota T; Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
Kohara J; Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
Goto W; Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
Shiraki A; Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
Dong L; Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
Takeda C; Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
Fukagawa H; Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
Źródło:
Asian journal of anesthesiology [Asian J Anesthesiol] 2019 Sep 01; Vol. 57 (3), pp. 101-108. Date of Electronic Publication: 2019 Oct 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 2018- : [Taipei] : Airiti
Original Publication: [Taipei] : Elsevier Taiwan LLC., [2017]-
MeSH Terms:
Anesthesia, General*
Cerebral Revascularization*
Nomograms*
Carbon Dioxide/*blood
Moyamoya Disease/*surgery
Adult ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies
Substance Nomenclature:
142M471B3J (Carbon Dioxide)
Entry Date(s):
Date Created: 20191115 Date Completed: 20200831 Latest Revision: 20200831
Update Code:
20240105
DOI:
10.6859/aja.201909_57(3).0005
PMID:
31722508
Czasopismo naukowe
Objective: The Radford nomogram, an old mathematical chart device to estimate the required ventilation for maintaining normocapnia, remains unvalidated in patients undergoing modern, balanced anesthesia. This study aims to investigate the performance of the Radford nomogram in patients undergoing general anesthesia and derive a simple equation to estimate the minute volume required to attain normocapnia (MVnorm).
Methods: This single-center retrospective study enrolled 78 patients (age ≥ 18 years) undergoing cerebral revascularization for Moyamoya disease. We defi ned MVnorm as the median of all values of the minute volume during normocapnia (estimated PaCO2: 38–42 mmHg). We examined the agreement level between the estimated minute volume using the Radford nomogram and MVnorm using the Bland–Altman analysis. Furthermore, we developed and validated a simple equation predicting MVnorm based on gender and a multiple of body weight, using a split-sample validation technique.
Results: The Radford nomogram tended to overestimate MVnorm with a mean bias of 560 mL/min (95% limits of agreement, -848–1,968 mL/min). The equation developed using data from the development group (n = 52): required minute volume (mL/min) = 85 × body weight (kg) in male patients and 70 × body weight (kg) in female patients. In the validation group (n = 26), the mean bias of this simple equation was 224 mL/min (95% limits of agreement, -1,264–1,712 mL/min).
Conclusion: The Radford nomogram overestimates MVnorm in modern, balanced anesthesia. The simple equation using gender and a multiple of body weight yields similar predictive performance to the Radford nomogram.

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