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Tytuł:
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Production of U for targeted alpha therapy.
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Autorzy:
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Friend MT; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Mastren T; Nuclear Engineering Program, Department of Civil and Environmental Engineering, University of Utah, 110 Central Campus Drive, Suite 2000b, Salt Lake City, UT, 84112, USA; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Parker TG; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Vermeulen CE; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Brugh M; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Birnbaum ER; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Nortier FM; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
Fassbender ME; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA. Electronic address: .
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Źródło:
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Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2020 Feb; Vol. 156, pp. 108973. Date of Electronic Publication: 2019 Nov 05.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Oxford ; New York : Pergamon Press, c1993-
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MeSH Terms:
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Alpha Particles*
Protactinium/*chemistry
Radioisotopes/*chemistry
Thorium/*chemistry
Protons
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Contributed Indexing:
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Keywords: Isotope production; Protactinium-230; Proton irradiation; Targeted alpha therapy; Thorium-226; Uranium-230
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Substance Nomenclature:
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0 (Protactinium-230)
0 (Protons)
0 (Radioisotopes)
0S6855V29M (Protactinium)
60YU5MIG9W (Thorium)
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Entry Date(s):
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Date Created: 20191116 Date Completed: 20201118 Latest Revision: 20201118
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Update Code:
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20240104
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DOI:
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10.1016/j.apradiso.2019.108973
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PMID:
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31727509
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Uranium-230 (t 1/2 = 20.8 d) is an alpha-emitting radionuclide that has potential application in targeted alpha therapy (TAT) of cancer. Its parent isotope 230 Pa (t 1/2 = 17.4 d), can be produced by proton irradiation of thorium metal targets. Preliminary 230 Pa production runs were performed at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF) using thin thorium metal targets and a proton beam energy of 15-30 MeV, followed by radiochemical separation of 230 Pa from the irradiated target matrix. The measured 230 Pa production yields were found to exceed the predicted values in most of the experiments that were performed. This data will inform further production efforts for providing 230 Pa/ 230 U for clinical trials.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
