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Tytuł pozycji:

Wharton's Jelly Mesenchymal Stromal Cells from Human Umbilical Cord: a Close-up on Immunomodulatory Molecules Featured In Situ and In Vitro.

Tytuł :
Wharton's Jelly Mesenchymal Stromal Cells from Human Umbilical Cord: a Close-up on Immunomodulatory Molecules Featured In Situ and In Vitro.
Autorzy :
Corsello T; Unit of Histology and Embryology, Department of Biomedicine Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Via del Vespro 129, 90127, Palermo, PA, Italy.; Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.
Amico G; Ri.MED Foundation, Palermo, Italy.; Department of Research, IRCCS ISMETT, Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Palermo, Italy.
Corrao S; Unit of Histology and Embryology, Department of Biomedicine Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Via del Vespro 129, 90127, Palermo, PA, Italy.; Ri.MED Foundation, Palermo, Italy.
Anzalone R; Department of Surgical, Oncological and Stomatological Sciences (DICHIRONS), University of Palermo, Via del Vespro 129, 90127, Palermo, PA, Italy. .
Timoneri F; Ri.MED Foundation, Palermo, Italy.; Department of Research, IRCCS ISMETT, Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Palermo, Italy.
Lo Iacono M; Campus of Hematology F. and P. Cutino, Villa Sofia-Cervello Hospital, Palermo, Italy.
Russo E; Unit of Histology and Embryology, Department of Biomedicine Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Via del Vespro 129, 90127, Palermo, PA, Italy.
Spatola GF; Unit of Histology and Embryology, Department of Biomedicine Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Via del Vespro 129, 90127, Palermo, PA, Italy.
Uzzo ML; Unit of Histology and Embryology, Department of Biomedicine Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Via del Vespro 129, 90127, Palermo, PA, Italy.
Giuffrè M; Department PROMISE, University of Palermo, Palermo, Italy.
Caprnda M; 2nd Department of Internal Medicine, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia.
Kubatka P; Department of Biology, Jessenius Faculty of Medicine in Martin, Martin, Slovakia.; Comenius University in Bratislava, Bratislava, Slovakia.
Kruzliak P; Department of Internal Medicine, Brothers of Mercy Hospital, Brno, Czech Republic.; 2nd Department of Surgery, Faculty of Medicine, Masaryk University and St. Anne's University Hospital, Brno, Czech Republic.
Conaldi PG; Department of Research, IRCCS ISMETT, Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Palermo, Italy.
La Rocca G; Unit of Histology and Embryology, Department of Biomedicine Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Via del Vespro 129, 90127, Palermo, PA, Italy. .
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Źródło :
Stem cell reviews and reports [Stem Cell Rev Rep] 2019 Dec; Vol. 15 (6), pp. 900-918.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: 2011- : [New York, NY] : Springer Science+Business Media
Original Publication: [Totowa, N.J.] : Humana Press, [2009]-
MeSH Terms :
Cell Differentiation*
B7 Antigens/*antagonists & inhibitors
Lymphocyte Activation/*immunology
Mesenchymal Stem Cells/*immunology
Umbilical Cord/*immunology
Wharton Jelly/*immunology
B7 Antigens/immunology ; Cell Proliferation ; Cells, Cultured ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; In Vitro Techniques ; Mesenchymal Stem Cells/cytology ; Umbilical Cord/cytology ; Wharton Jelly/cytology
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Contributed Indexing :
Keywords: B7-H3*; CD276*; Cell therapy*; Human umbilical cord*; Immunomodulation*; Lymphocyte inhibition*; Regenerative medicine*; Stem cells*; Wharton’s jelly mesenchymal stromal cells*
Substance Nomenclature :
0 (B7 Antigens)
0 (CD276 protein, human)
0 (Cytokines)
Entry Date(s) :
Date Created: 20191120 Date Completed: 20200804 Latest Revision: 20200928
Update Code :
20201023
DOI :
10.1007/s12015-019-09907-1
PMID :
31741193
Czasopismo naukowe
Therapeutic options for end-stage organ failure are often limited to whole organ transplantation. The tolerance or rejection of the transplanted organ is driven by both early non-specific innate and specific adaptive responses. The use of mesenchymal stromal cells (MSCs) is considered a promising tool in regenerative medicine. Human umbilical cord (HUC) is an easily available source of MSCs, without relevant ethical issues. Moreover, Wharton's jelly-derived MSCs (WJ-MSCs), showed consistent immunomodulatory features that may be useful to promote immune tolerance in the host after transplantation. Few data are available on the phenotype of WJ-MSCs in situ. We investigated the expression of immune-related molecules, such as HLAs, IDO, CD276/B7-H3, and others, both in situ (HUC) and in in vitro-cultured WJ-MSCs. Morphological and biochemical techniques were used to define the expression of such molecules. In addition, we focused on the possible role of CD276/B7-H3 on T cells proliferation inhibition. We assessed CD276/B7-H3 expression by WJ-MSCs both in situ and alongside cell culture. WJ-MSCs were able to suppress T cell proliferation in mixed lymphocyte reaction (MLR). Moreover, we describe for the first time a specific role for CD276/B7-H3, since the immunomodulatory ability of WJ-MSCs was abolished upon anti-CD276/B7-H3 antibody addition to the MLR. These results further detail the immune regulation properties and tolerance induction exerted by human WJ-MSCs, in particular pointing to CD276/B7-H3 as one of the main involved factors. These data further suggest WJ-MSCs as potent tools to modulate local immune response in "support-type" regenerative medicine approaches.

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