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Tytuł:
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Prevalence of multidrug resistance tuberculosis in adult patients in India: A systematic review and meta-analysis.
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Autorzy:
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Charan J; Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Tank N; Department of Pharmacology, GMERS Medical College, Himmatnagar, Gujarat, India.
Reljic T; Department of Comparative Effectiveness Research, University of South Florida, Tampa, FL, USA.
Singh S; Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Bhardwaj P; Department of Community and Family Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Kaur R; Department of Pharmacology, S. N. Medical College, Jodhpur, Rajasthan, India.
Goyal JP; Department of Paediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Kumar A; Department of Comparative Effectiveness Research, University of South Florida, Tampa, FL, USA.
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Źródło:
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Journal of family medicine and primary care [J Family Med Prim Care] 2019 Oct 31; Vol. 8 (10), pp. 3191-3201. Date of Electronic Publication: 2019 Oct 31 (Print Publication: 2019).
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Mumbai : Medknow
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References:
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Niger Med J. 2014 Jul;55(4):327-32. (PMID: 25114369)
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Contributed Indexing:
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Keywords: India; multidrug resistance tuberculosis; prevalence; resistance; tuberculosis
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Entry Date(s):
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Date Created: 20191120 Latest Revision: 20220411
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Update Code:
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20240104
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PubMed Central ID:
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PMC6857375
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DOI:
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10.4103/jfmpc.jfmpc_542_19
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PMID:
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31742141
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Background: Multidrug resistance tuberculosis (MDR-TB) is an important public health problem for India but there is a paucity of data related to the prevalence of MDR-TB in India. This systematic review and meta-analysis was designed to synthesize evidence regarding the prevalence of MDR-TB in adult patients in India.
Methods: PubMed and Google Scholar were searched to find different observational studies reporting MDR-TB prevalence in India. Data related to MDR-TB prevalence were pooled for the analysis. PubMed was searched by using different MeSH words. Prevalence was reported with 95% confidence interval (CI). A separate analysis was done for new cases and previously treated cases. Random effect model was used and heterogeneity was assessed by I 2 and Cochran Q test.
Results: MDR-TB prevalence in new cases were 3% (95% CI 2%-5%, I 2 = 95.3%). There was difference in prevalence between different methods of measurement of MDR-TB and study designs. MDR-TB prevalence in previously treated cases was found to be 35% (95% CI 29%-41%, I 2 = 98.7%). Results vary with the method of measurement as well as the study design.
Conclusion: MDR-TB prevalence in previously treated patients was found higher compared to the reported values in national surveys. There is a need for large scale cross-sectional study to verify the findings observed in this review.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2019 Journal of Family Medicine and Primary Care.)
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