Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction.

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Abstrakt

Tytuł:: Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction.
Autorzy:: Wang H; Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, 272029, Shandong, China.
Zhang S; Division of Cardiology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Wang N; Division of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Zhang J; Division of Cardiology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Chen M; Division of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
He X; Division of Cardiology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Cui Y; Cardiac Care Unit, Affiliated Hospital of Jining Medical Uniiversity, Jining Medical University, Jining, Shandong, China.
Pang S; Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, 272029, Shandong, China. .
Yan B; Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, 272029, Shandong, China. .
Źródło:: Human genomics [Hum Genomics] 2019 Nov 19; Vol. 13 (1), pp. 56. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2012- : London : BioMed Central
Original Publication: London : Henry Stewart Publications, c2003-
MeSH Terms:: Genetic Variation*
Promoter Regions, Genetic*
Myocardial Infarction/*genetics
Vascular Endothelial Growth Factor Receptor-1/*genetics
5' Untranslated Regions/genetics ; Adult ; Aged ; Aged, 80 and over ; Animals ; Base Sequence ; Binding Sites ; Biotinylation ; Case-Control Studies ; Female ; Genes, Reporter ; Genetic Predisposition to Disease ; HEK293 Cells ; Humans ; Luciferases/metabolism ; Male ; Mice ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Young Adult
References:: Nat Genet. 2013 Jan;45(1):25-33. (PMID: 23202125)
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D91-4. (PMID: 14681366)
Heart Dis. 2000 Jul-Aug;2(4):314-25. (PMID: 11728275)
Vascul Pharmacol. 2006 May;44(5):265-74. (PMID: 16545987)
Circ Res. 2008 Oct 24;103(9):1027-36. (PMID: 18802023)
Hypertension. 2016 Sep;68(3):678-87. (PMID: 27480835)
Cardiol Rev. 2008 Sep-Oct;16(5):219-29. (PMID: 18708823)
Atherosclerosis. 2011 Dec;219(2):851-4. (PMID: 21943873)
J Am Coll Cardiol. 2016 Dec 27;68(25):2797-2818. (PMID: 28007143)
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9349-54. (PMID: 9689083)
Eur Heart J. 2011 Feb;32(3):326-35. (PMID: 21138939)
J Am Coll Cardiol. 2006 Jul 4;48(1):43-50. (PMID: 16814647)
Circ Heart Fail. 2016 Jan;9(1):e002115. (PMID: 26699385)
FEBS Lett. 1995 Aug 21;370(3):203-8. (PMID: 7656977)
Physiol Rev. 2014 Jul;94(3):779-94. (PMID: 24987005)
Biochem Biophys Res Commun. 2018 Jan 1;495(1):884-891. (PMID: 29158084)
Nat Med. 2003 Jul;9(7):936-43. (PMID: 12796773)
Placenta. 2009 Jan;30(1):25-34. (PMID: 19010535)
Cardiovasc Res. 2011 Feb 1;89(2):410-8. (PMID: 20935166)
J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):724-728. (PMID: 27694344)
Circ J. 2012;76(6):1331-2. (PMID: 22510821)
Basic Res Cardiol. 2015 May;110(3):30. (PMID: 25893874)
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10705-9. (PMID: 8248162)
J Biol Chem. 1997 Sep 19;272(38):23659-67. (PMID: 9295307)
J Hum Genet. 2016 Jan;61(1):71-7. (PMID: 26134515)
Circulation. 2009 Feb 17;119(6):845-56. (PMID: 19188502)
Oncotarget. 2016 Nov 8;7(45):72868-72885. (PMID: 27655684)
J Am Coll Cardiol. 2015 Mar 3;65(8):830-845. (PMID: 25720628)
J Am Coll Cardiol. 2011 Jul 19;58(4):386-94. (PMID: 21757116)
Angiogenesis. 2006;9(4):225-30; discussion 231. (PMID: 17109193)
Circ Res. 2016 Feb 19;118(4):564-78. (PMID: 26892958)
FASEB J. 2010 May;24(5):1467-78. (PMID: 20019242)
Circulation. 2009 Dec 15;120(24):2470-7. (PMID: 19948974)
Gene Rep. 2018 Jun;11:94-100. (PMID: 30873504)
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5780-5. (PMID: 11331753)
Circ Res. 2014 Jun 6;114(12):1890-903. (PMID: 24902973)
J Leukoc Biol. 2011 Jul;90(1):199-204. (PMID: 21447646)
J Cell Sci. 2002 Jun 15;115(Pt 12):2559-67. (PMID: 12045226)
Kidney Int. 2014 Feb;85(2):393-403. (PMID: 24048373)
Shock. 2006 Oct;26(4):332-41. (PMID: 16980878)
Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):null. (PMID: 22908198)
Circ Res. 2004 Oct 29;95(9):884-91. (PMID: 15472115)
Nat Med. 2001 May;7(5):575-83. (PMID: 11329059)
Circ J. 2012;76(6):1509-16. (PMID: 22452999)
Biochem Biophys Res Commun. 2019 Apr 9;511(3):650-657. (PMID: 30826058)
Hypertension. 2019 May;73(5):1104-1111. (PMID: 30879360)
Atherosclerosis. 2008 Apr;197(2):753-6. (PMID: 17707383)
Clin Exp Med. 2011 Jun;11(2):113-21. (PMID: 20821246)
Grant Information:: ZR2015HL007 International Natural Science Foundation of Shandong Province (CN); JY2015KJ035 International Scientific Research Project of Jining Medical University
Contributed Indexing:: Keywords: Acute myocardial infarction; DNA sequence variants; Genetics; Promoter; VEGFR-1
Substance Nomenclature:: 0 (5' Untranslated Regions)
0 (Transcription Factors)
EC 1.13.12.- (Luciferases)
EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
Entry Date(s):: Date Created: 20191121 Date Completed: 20200518 Latest Revision: 20200518
Update Code:: 20240104
PubMed Central ID:: PMC6862733
DOI:: 10.1186/s40246-019-0243-1
PMID:: 31744542
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Background: Coronary artery disease (CAD) including acute myocardial infarction (AMI) is a common complex disease caused by atherosclerosis. Vascular epithelial growth factor receptor-1 (VEGFR-1) stimulates angiogenesis and vascular permeability, and functions as a decoy to sequester VEGF and prevent initiation of intracellular signaling. VEGFR-1 knockout mice exhibit significantly higher mortality due to heart failure, cardiac hypertrophy, and cardiac dysfunction. An evident increase in macrophage infiltration and cardiac fibrosis are also observed after transverse aortic constriction. Therefore, VEGFR-1 gene variants may be involved in CAD. In this study, VEGFR-1 gene promoter was genetically and functionally analyzed in large cohorts of AMI patients and ethnic-matched controls.
Results: A total of 16 DNA sequence variants (DSVs) including six single-nucleotide polymorphisms (SNPs) were found in the VEGFR-1 gene promoter and 5'-untranslated region. Five novel DSVs and one SNP were only identified in AMI patients group. These DSVs and SNP significantly altered the transcriptional activity of the VEGFR-1 gene promoter in both HEK-293 and H9c2 cells (P < 0.05). Further electrophoretic mobility shift assay indicated that the DSVs and SNPs evidently affected the binding of transcription factors.
Conclusions: The genetic variants in VEGFR-1 gene identified in AMI patients may alter the transcriptional activity of the VEGFR-1 gene promoter and change VEGFR-1 level, contributing to AMI development.

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